The Caffeine Therapy in the Fetal to Neonatal Transition

Launched by HOSPITAL DE CLINICAS DE PORTO ALEGRE · Jul 7, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the effects of giving caffeine to premature newborns who weigh less than 1250 grams and are on noninvasive mechanical ventilation. Researchers want to find out if starting caffeine in the first two hours after birth is more beneficial than waiting until 24 hours after birth. The main goals are to see if early caffeine treatment can reduce the need for more invasive breathing support (intubation) and shorten the time these babies spend on mechanical ventilation. The trial will involve 50 babies, divided into two groups: one will receive caffeine soon after birth, while the other will be given a placebo (an inactive substance) to keep the study fair and unbiased.

To participate in this trial, babies need to be born prematurely, weigh less than 1250 grams, and not require intubation right after delivery. Babies born at other hospitals or those with serious congenital problems will not be included. Families can expect that their baby will either receive caffeine early or at a later time, and the researchers will carefully monitor the babies for any potential complications related to prematurity, such as lung problems or other health issues. Overall, this study hopes to improve care for premature infants and help them have better health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Premature newborns with birth weight less than 1250 grams
• • Who are not intubated in the delivery room
• Exclusion Criteria:
• • Premature newborns from other hospitals
• • Presence of a major congenital malformation or genetic syndrome