Optical Neuroimaging and Cognition

Launched by UNIVERSITY OF CAMBRIDGE · Jul 11, 2022

Keywords

ClinConnect Summary

This clinical trial, called "Optical Neuroimaging and Cognition," is researching how brain oxygen levels and metabolism change in people with different types of dementia, including Alzheimer's Disease and Dementia with Lewy Bodies. The study will use a new imaging technique called near-infrared spectroscopy (NIRS), which is a safe and non-invasive method that uses light to measure brain activity. This technique is easier to tolerate than traditional imaging methods and can be done in a clinic or even at home, making it a promising option for monitoring dementia.

To participate in the trial, individuals must be between the ages of 65 to 74 and have a diagnosis of Lewy Body Dementia, Alzheimer's Disease, or Mild Cognitive Impairment. Those who are cognitively normal but have a good understanding of English and can provide consent are also eligible. Participants can expect to undergo tests that measure their brain's oxygen levels and metabolism, helping researchers identify important markers for dementia. It’s important to note that individuals with severe dementia or certain medical conditions, like significant mental illnesses or specific physical limitations, may not qualify for the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• 1. A diagnosis of probable:
• • Lewy Body Dementia
• • Alzheimer's Disease
• • Mild Cognitive Impairment (MCI-LB or MCI-AD) OR
• • 2. Cognitively normal for their education and age, with a MMSE score above 26 AND
• • A good grasp of the English language
• • An informant (either a carer or family member) who will be available throughout testing (only relevant if in a patient group)
• Exclusion Criteria:
• • 1. Severe dementia
• • Unable to participate
• • A MMSE score below 12
• • 2. A condition which influences metabolism or haemodynamics
• • Such as metabolic or respiratory disorders
• • 3. A significant mental illness
• • Such as rheumatoid arthritis, systemic lupus erythematosus
• • Oral steroid use
• • 4. A significant psychiatric disorder
• • 5. MCI due to other causes such as traumatic brain injury, vascular dementia, or fronto-temporal dementia
• • 6. A history of excessive drug or alcohol use
• • 7. Contraindications to MRI (only for patient groups undertaking the MRI scan: AD/MCI/DLB)
• • Surgical implants e.g. pacemakers
• • Obesity