Treatment Preventive for Pre-eclampsia by Acetylsalicylic Acid in Women Who Underwent Frozen Embryo Transfer

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE LIEGE · Jul 13, 2022

Keywords

ClinConnect Summary

This clinical trial is studying whether taking a low dose of acetylsalicylic acid (commonly known as aspirin) can help prevent pre-eclampsia in pregnant women who have undergone frozen embryo transfer. Pre-eclampsia is a condition that can occur during pregnancy, causing high blood pressure and other health issues. The trial is currently looking for healthy women aged 18 to 43 who are planning to have a frozen embryo transfer and have confirmed their pregnancy by six weeks.

To participate, women must not have certain risk factors for pre-eclampsia, such as a history of the condition, being significantly overweight, or having other health issues like untreated high blood pressure or diabetes. Participants in the trial will take the low-dose acetylsalicylic acid and will be monitored to see if it helps reduce the chances of developing pre-eclampsia. It's essential for potential participants to understand the inclusion and exclusion criteria to determine if they are eligible for this important research study.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Healthy women from \[18 - 43\] years-old, planned for a frozen embryo transfer, with natural and modified natural or HRT cycle
• • Who have given their informed consent
• • Who have a confirmed pregnancy at week 6 of amenorrhea.
• Exclusion Criteria:
• • Women presenting one risk factor for preeclampsia: multiple pregnancy, history of preeclampsia, BMI \> 30, lupus syndrome, preexistent proteinuria, non-treated chronic high blood pressure (\>140/90), antiphospholipid antibody syndrome, diabetes (fasting blood sugar \>126mg/dl)
• • Contraindication to acetylsalicylic acid (at risk of active hemorrhage (like hemophilia, ...); at risk of or who have a gastro-duodenal ulcer; at risk or how have a terminal renal or hepatic in-sufficiency (only if acetylsalicylic acid is given at high dose)
• • Already treated with acetylsalicylic acid
• • Treatment with anticoagulants or non-steroid anti-inflammatory drugs