Impact of Nocturnal Hypoxemia on Glucose in High Altitude Sleep Disordered Breathing

Launched by JOHNS HOPKINS UNIVERSITY · Jul 14, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how low oxygen levels at night, which can occur in people who live at high altitudes, affect their blood sugar control. The researchers believe that improving oxygen levels during sleep might help people in these areas manage their blood sugar better and reduce the risk of diabetes. The study will involve residents of Puno, Peru, who will receive supplemental oxygen in a random order to see how it impacts their glucose levels.

To participate in this study, you need to be a permanent resident of Puno, Peru, and be between the ages of 16 and 65. However, certain conditions may prevent you from joining, such as having diabetes, using oxygen therapy, or experiencing other serious health issues. If you decide to participate, you can expect to take part in a study that aims to understand a potential way to improve health for people living at high altitudes. This research could help improve blood sugar control for many in your community.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Permanent residents of Puno, Peru
• Exclusion Criteria:
• • Recent travel to low altitude (\<3000 m)
• • Oxygen use
• • Pregnancy
• • Morbid obesity (BMI \> 40 kg/m2)
• • Current smoking
• • Diabetes
• • Other sleep disorders (e.g. circadian rhythm disorder or insomnia)
• • Use of open fires in the home (i.e. for cooking or heat)
• • Chronic Mountain Sickness (CMS) as defined by a daytime oxyhemoglobin saturation \< 85%, Qinghai CMS \>10 or excessive erythrocytosis as defined by hemoglobin \>19 g/dL in women or \>21 g/dL in men.