SV2A in Older Adults

Launched by YALE UNIVERSITY · Jul 16, 2022

Keywords

ClinConnect Summary

The clinical trial titled "SV2A in Older Adults" is investigating how cannabis use affects the brain's synaptic density in older adults. Essentially, the study aims to see how cannabis may influence the connections between brain cells by using a special imaging technique called PET imaging. The trial is currently recruiting participants who are at least 50 years old and do not have significant medical or neurological issues. Both men and women can participate, but women who can become pregnant must agree to use effective birth control during the study.

If you decide to participate, you can expect to undergo PET scans to help researchers learn more about the brain's structure and how it may change with cannabis use. It's important to note that participants cannot have certain medical conditions, such as bleeding disorders, or recent exposure to radiation that could complicate the study. This trial will provide valuable insights into how cannabis affects older adults, and your involvement could help improve understanding of its impact on brain health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Able to provide informed consent
• • Male or female, aged ≥50 years
• • No history of significant medical or neurological disease
• • BMI ≤ 50
• • If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans
• Exclusion Criteria:
• • Women with a positive pregnancy test or women who are lactating
• • Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
• • History of a bleeding disorder or are currently taking anticoagulants
• • Subjects who have donated blood within 8 weeks of the present study