Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders

Launched by MAYO CLINIC · Jul 22, 2022

Keywords

ClinConnect Summary

This clinical trial is focused on understanding Amyotrophic Lateral Sclerosis (ALS), a serious disease that affects the nerves and muscles. The researchers aim to gather important information and blood samples from people diagnosed with ALS, their family members, and healthy individuals. This data will help scientists explore the genetic factors that may contribute to ALS in the future. The trial is currently looking for participants, including individuals aged 18 and older who have been diagnosed with ALS or have a family history of ALS. Healthy individuals without any personal or family history of ALS or other neurodegenerative diseases can also join.

If you choose to participate, you'll be asked to provide some blood samples and share your medical history. This is an opportunity to contribute to valuable research that could lead to better understanding and treatment of ALS. It's important to know that some conditions may prevent you from joining, such as having a history of other neurodegenerative diseases or if you're unable to give consent. Overall, your involvement could be key in helping future patients dealing with ALS.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • ALS or Suspected ALS Patient
• • Clinical diagnosis of possible, laboratory-supported probable, probable or definite ALS according to modified EL Escorial criteria, suspected ALS according to original El Escorial criteria, or diagnosis of a neurodegenerative disorder with evidence of ALS plus extramotor features; OR
• * Blood relative (first, second or third degree) with history of ALS or neurodegenerative disorder with evidence of ALS plus extramotor features; OR:
• • A clinical suspicion or referral for ALS;
• • \> 18 years of age;
• • Willing and able to give signed informed consent or assent that has been approved by the Institutional Review Board (IRB).
• • Blood Relative of ALS Patient
• • Family history (first, second or third degree blood relative) of ALS or other motor neuron disease;
• • \> 18 years of age;
• • Willing and able to give signed informed consent that has been approved by the Institutional Review Board (IRB).
• • Healthy Control
• • No personal or family history (first, second or third degree blood relative) of ALS or other motor neuron disease;
• • \> 18 years of age;
• • No personal history of other neurodegenerative disease (i.e., Alzheimer disease, Parkinson disease);
• • Willing and able to give signed informed consent that has been approved by the Institutional Review Board (IRB).
• Exclusion Criteria:
• • ALS or Suspected Patient • Limited mental capacity rendering the subject unable to provide written informed consent or assent or comply with standard phlebotomy procedures.
• • Blood Relative of ALS Patient
• • • Limited mental capacity rendering the subject unable to provide written informed consent or comply with standard phlebotomy procedures.
• • Healthy Control Subject
• • Personal or family history of dementia or other neurodegenerative disease (Parkinson disease, Alzheimer disease, etc.);
• • Limited mental capacity rendering the subject unable to provide written informed consent or comply with standard phlebotomy procedures.