Minocycline for Chronic Autoimmune Uveitis

Launched by SUN YAT-SEN UNIVERSITY · Jul 24, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the use of a medication called minocycline to treat patients with chronic autoimmune uveitis, a serious eye condition that can lead to vision loss due to persistent inflammation. The trial aims to see if minocycline can help improve eye health and protect against further damage, especially for those experiencing retinal degeneration. Currently, many existing treatments are not very effective, so researchers are hopeful that minocycline might offer a new option for patients.

To participate in the trial, individuals must be between 18 and 60 years old and have been diagnosed with autoimmune diseases that have affected their vision. They also need to be able to commit to attending follow-up visits and must provide informed consent. However, certain individuals cannot participate, such as those who are allergic to minocycline, have specific medical conditions, or are currently taking certain other medications. If eligible, participants can expect to receive the study medication and be monitored for its effects on their eye health. This trial is currently recruiting participants, and it represents an important step towards finding better treatments for this challenging condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Participant diagnosed of autoimmune diseases with visual function damage (decrease of BCVA, loss of retinal structure)
• • Participant aged from 18-60 years old.
• • Participant that signed the informed consent document and is able to complete the following visits.
• Exclusion Criteria:
• • Participant is allergy to minocycline or tetracyclines.
• • Participant has no contraindications of minocycline or tetracyclines.
• • Participant has an abnormal function of liver, heart, kidney and thyroid.
• • Participant is using glucocorticoids, immunosuppressants or biologics.
• • Female that is pregnant, breast-feeding or planning to become pregnant.
• • Participant that is currently using other medications for other diseases.