Cortico-cortical Stimulation and Robot-assisted Therapy for Upper Limb Recovery After Stroke (CCS&RAT)

Launched by I.R.C.C.S. FONDAZIONE SANTA LUCIA · Jul 26, 2022

Keywords

ClinConnect Summary

The clinical trial titled "Cortico-cortical Stimulation and Robot-assisted Therapy for Upper Limb Recovery After Stroke" is looking into a new way to help people recover use of their arms after having a stroke. This study is testing a combination of two treatments: a special brain stimulation technique that targets specific areas of the brain involved in movement, and robot-assisted therapy that helps patients practice moving their arms. By working together, these methods aim to improve the recovery of upper limb function in individuals who have experienced their first stroke and still have some difficulty using their arm.

To be eligible for this trial, participants need to be between 65 and 74 years old, or 29 to 219 years old, and have experienced a chronic ischemic stroke that has left them with moderate to severe difficulty in using their affected arm. However, some individuals may not qualify, including those with a history of seizures, other serious health issues, or certain cognitive impairments. Participants can expect to engage in both brain stimulation and robot-assisted therapy sessions, which are designed to support their recovery. This trial is currently recruiting, and having the chance to join could mean accessing cutting-edge therapies that may benefit upper limb recovery after a stroke.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. first ever chronic ischemic stroke;
• • 2. hemiparesis due to left or right subcortical or cortical lesion in the territory of the middle cerebral artery;
• • 3. severe or moderate residual upper limb impairment (FMA \< 52 in the motor domain A/D)
• Exclusion Criteria:
• • 1. history of seizures;
• • 2. severe general impairment or concomitant diseases;
• • 3. treatment with benzodiazepines, baclofen, and antidepressants;
• • 4. Intracranial metal implants;
• • 5. cardiac pacemaker;
• • 6. pregnancy status;
• • 7. orthopedic contraindications for upper limb;
• • 8. upper limb pain;
• • 9. cognitive impairment (MMSE \< 23);
• • 10. presence of unilateral spatial neglect