Chinese Longitudinal and Systematic Study of Bioplar Disorder

Launched by FIRST AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY · Jul 28, 2022

Keywords

ClinConnect Summary

This clinical trial, called the Chinese Longitudinal and Systematic Study of Bipolar Disorder, is investigating how certain factors, including gut microbes, can affect mental health conditions like Major Depressive Disorder and Bipolar Disorder. The researchers aim to create a large group of participants to identify helpful biological markers that can assist in diagnosing these mood disorders and predicting how well treatments might work. By examining things like gut bacteria, blood samples, and brain imaging, they hope to find new ways to understand and treat these challenging conditions.

To be eligible for this study, participants should be between the ages of 16 and 65 and have a diagnosis of Major Depressive Disorder or Bipolar Disorder. It's important that they do not have any major cognitive impairments, serious medical conditions, or have taken certain medications recently. Participants can expect to undergo various tests, including blood tests and brain scans, to help researchers learn more about the connections between gut health and mood disorders. This study is currently recruiting and welcomes individuals of all genders who meet the inclusion criteria.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Both biological parents are Han nationality;
• • 2. Aged 16-65;
• • 3. The subjects met the clinical diagnostic criteria of DSM-5 for depressive episodes of MDD/BD;
• • 4. Did not take any immunomodulatory preparations within 1 month before enrollment;
• • 5. No clear history of respiratory tract, urinary system, digestive system infection within 1 month before enrollment;
• Exclusion Criteria:
• • 1. Those with schizophrenia spectrum, neurodevelopmental disorder, dementia, memory impairment or other cognitive impairment that meet the DIAGNOSTIC criteria of DSM-5;
• • 2. Mental disorders caused by substance abuse (alcohol, drugs, etc.), patients suffering from serious physical diseases and immune system diseases, such as diabetes, thyroid diseases, hypertension, heart disease, liver and kidney dysfunction, autoimmune diseases, etc.;
• • 3. Had received medication (such as antidepressants, antipsychotics, mood stabilizers, etc.) within 1 month before enrollment;
• • 4. those who had used ECT before enrollment;
• • 5. Currently have serious suicidal thoughts or behaviors, or serious excitement;
• • 6. those who cannot follow the doctor's advice or have no guardian;
• • 7. pregnant or breast-feeding women, or those who plan to become pregnant;
• • 8. Contraindications to MRI examination;
• • 9. Other conditions that the researcher considers inappropriate for inclusion.