An Exploratory Study to Evaluate Immune Determinants of the Response to Adoptive Cell Therapy (ACT) in Solid and Hematologic Tumors

Launched by GUSTAVE ROUSSY, CANCER CAMPUS, GRAND PARIS · Jul 28, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how certain treatments called adoptive cell therapy (ACT) affect the immune system in patients with solid tumors and blood cancers. Researchers want to understand how these therapies change the cells in tumors, blood, and bone marrow, and how these changes relate to how well the treatment works or any side effects that may occur. Essentially, the study aims to find out what makes the treatment effective or causes problems by looking at the characteristics of immune cells before and after therapy.

To participate in this study, patients must be at least 2 years old and have a tumor that can be biopsied—meaning a sample can be taken safely for testing. They should also be affiliated with a social security regimen and capable of following the study's requirements. Participants will undergo tests that involve taking samples from their tumors, blood, and bone marrow, and they will be closely monitored throughout the study. It's important to note that pregnant or nursing women cannot join this trial, and those with certain blood clotting issues may have restrictions on biopsies but can still provide blood and bone marrow samples.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient affiliated to a social security regimen
• • Tumor lesion accessible to core biopsies
• • Patient who is fully informed, able to comply with the protocol and who signed the informed consent
• • Pediatric patients \> than 2 years old can be included
• • No restriction about the Eastern Cooperative Oncology Group (ECOG) status
• Exclusion Criteria:
• • Coagulation abnormality prohibiting a biopsy (but patients can still give their consent for blood and bone marrow samples).
• • Tumor lesion not accessible to core biopsies.
• • Pregnant or nursing women cannot participate in this study.