Micro- and Macrovascular Parameters in Delayed Cerebral Ischemia

Launched by MAASTRICHT UNIVERSITY MEDICAL CENTER · Jul 29, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a condition called delayed cerebral ischemia (DCI), which can occur after a type of brain bleeding known as aneurysmal subarachnoid hemorrhage (aSAH). DCI can happen due to various factors that affect blood flow in the brain. The researchers want to explore how a protective layer in the blood vessels, called the glycocalyx, may play a role in DCI. They will do this by measuring the glycocalyx in patients using special imaging techniques and blood tests. The trial also aims to see if changes in the glycocalyx are linked to inflammation and blood flow patterns in the brain, which might help predict patient recovery over the following months.

To participate in this study, individuals need to be at least 18 years old and have a confirmed diagnosis of aneurysmal subarachnoid hemorrhage, which must be identified within 72 hours of the bleeding event. Patients who are very ill or have other specific medical conditions may not be eligible. Those who join the trial will undergo various tests to measure the glycocalyx and blood flow in the brain, and the results will help researchers understand more about DCI and its effects on patients' recovery. Overall, this study could provide valuable insights into how to better manage and treat this serious condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age ≥ 18 years
• • confirmed aneurysmal subarachnoid hemorrhage on CTA or DSA
• • inclusion within 72 hours after ictus
• Exclusion Criteria:
• • imminent death within 24 hours
• • other causes of subarachnoid hemorrhage like AVM or trauma
• • language barrier
• • ophthalmic or oral trauma or infection
• • absent temporal bone window for TCD