Neuropathic Pain and Operant Conditioning of Cutaneous Reflexes After SCI
Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Aug 5, 2022
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at a new way to help people who have neuropathic pain—pain that occurs after a spinal cord injury (SCI). The main focus is on using reflex training in the legs to see if it can reduce this type of pain. The researchers are inviting 15 individuals aged 65-74, who have been stable for at least a year after their injury, to take part in the study. To be eligible, participants should be able to stand for at least three minutes, and their pain must be in the lower legs.
If you decide to participate, you would need to attend about 50 visits over six and a half months, which includes training and follow-up appointments. This study could be a chance to explore a new method of pain relief, but it’s important to note that certain health conditions, like heart problems or cognitive impairments, may exclude someone from participating. Overall, this trial aims to improve the quality of life for those dealing with neuropathic pain after a spinal cord injury.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. neurologically stable (\>1 year post SCI)
- • 2. medical clearance to participate
- • 3. ability to stand with or without an assistive device for at least 3 minutes at a time
- • 4. expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted)
- • 5. For participants with neuropathic pain, the area of neuropathic pain must include lower leg.
- Exclusion Criteria:
- • 1. motoneuron injury
- • 2. known cardiac condition
- • 3. medically unstable condition (incl. pregnancy)
- • 4. cognitive impairment
- • 5. uncontrolled peripheral neuropathy
- • 6. frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment
- • 7. daily use of electrical stimulation to the leg
- • 8. complete lack of cutaneous sensation around foot.
About Medical University Of South Carolina
The Medical University of South Carolina (MUSC) is a leading academic health center dedicated to advancing medical research and improving patient care through innovative clinical trials. With a strong emphasis on translational medicine, MUSC leverages its extensive resources and expertise to facilitate groundbreaking studies across various medical disciplines. The institution is committed to fostering collaboration among researchers, healthcare professionals, and patients, ensuring that cutting-edge discoveries translate into effective treatments. As a pioneer in health education and research, MUSC plays a vital role in shaping the future of medicine and enhancing health outcomes in the community and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Charleston, South Carolina, United States
Patients applied
Trial Officials
Aiko Thompson, PhD
Principal Investigator
Medical University of South Carolina
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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