Proper Duration of Suppressive Antibiotic Therapy After Debridement, Antibiotics, and Implant Retention

Launched by UNIVERSITY OF MARYLAND, BALTIMORE · Aug 8, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how long patients should continue taking oral antibiotics after a specific surgical procedure called debridement, antibiotics, and implant retention (DAIR) for treating infections around joint implants. The goal is to find out the effects of these antibiotics on patients' health, including any side effects, the need for further surgeries due to infections, and the potential for developing antibiotic resistance.

To participate in the study, individuals need to be over 18 years old and have had the DAIR procedure for an acute joint infection that has lasted less than four weeks. They should also have been on oral antibiotics for at least three months after their surgery. Participants will be closely monitored to assess their health and any complications related to the antibiotic treatment. This study aims to provide clearer guidance on how to manage infections in joint replacement patients effectively.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • over 18 years-old
• • underwent DAIR with modular component exchange for acute TJA PJI, as defined by Musculoskeletal Infection Society Criteria, with symptom duration less than 4 weeks
• • on postoperative oral SAT for at least 3 months
• Exclusion Criteria:
• • underwent aseptic revision surgery
• • had one-stage, 1.5-stage, or two-stage revision surgery
• • did not have postoperative SAT
• • did not have follow-up that allowed for evaluation of SAT sequelae