Targeted Alpha Particle Radiotherapy for Metastatic Uveal Melanoma

Launched by MODULATION THERAPEUTICS, INC. · Aug 9, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring a new treatment called targeted alpha particle radiotherapy using a substance known as 225Ac-MTI-201 for patients with metastatic uveal melanoma, a type of eye cancer that has spread to other parts of the body. The main goal of the study is to find out the highest dose of this treatment that patients can tolerate without serious side effects. In addition, the researchers want to understand how the drug moves through the body and any potential toxic effects it might have.

To be eligible for this trial, participants must be adults aged 18 or older with a confirmed diagnosis of metastatic uveal melanoma that has worsened after at least one previous treatment. They should have measurable disease and good overall health, as indicated by specific blood test results. Participants will receive the treatment and be monitored closely for side effects and how well the treatment works. It's important for potential participants to know that certain health conditions, prior treatments, and pregnancy can affect their eligibility for this study. If you think you might qualify and are interested in learning more, please discuss it with your healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histologically confirmed metastatic uveal melanoma.
• • Progression after at least one prior line of therapy for metastatic uveal melanoma. Liver directed therapy (e.g., hepatic arterial embolization, isolated hepatic perfusion) will count as one line of therapy. Should any additional treatment(s) receive regulatory approval for metastatic uveal melanoma during the conduct of this trial, participants (if eligible for the newly approved treatment) would need to demonstrate disease progression on the additional treatment(s) before being eligible to participate in the current study. There is no limit to the number of previous treatments for metastatic disease.
• • Participants must have measurable disease per RECIST 1.1.
• • Adults, age 18 or over, with no upper age limit.
• • ECOG (Eastern Cooperative Oncology Group) performance status of 0-1 (Karnofsky ≥ 70 percent).
• * Acceptable organ and marrow function as defined below:
• • Leucocytes ≥ 3,000/μL
• • Absolute neutrophil count ≥ 1,500/μL
• • Platelets ≥ 100,000/μL
• • Aspartate aminotransferase (AST)/ Alanine aminotransferase (ALT) ≤ 2.5x institutional upper limit of normal (ULN)
• • Bilirubin ≤ 1.5x institutional upper limit of normal (ULN)
• • Creatinine clearance ≥ 60mL/min/1.73m\^2 (measured by Cockcroft-Gault equation using actual body weight in kilograms, and then adjusted for body surface area)
• • Male participants who are sexually active, and female participants of childbearing potential must agree to use 2 forms of FDA approved contraceptive methods during treatment with 225Ac-MTI-201 and up to 3 months following treatment.
• • Ability to understand and the willingness to sign a written informed consent document.
• Exclusion Criteria:
• • Prior alpha-particle therapy.
• • Has known symptomatic central nervous system (CNS) metastases and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are stable without evidence of progression by imaging for at least four weeks after definitive intervention and using no more than the equivalent of dexamethasone 2 mg/d for the management of vasogenic edema, if necessary. This exception does not include carcinomatous meningitis, which is excluded regardless of clinical stability.
• • Participants with an active malignancy requiring anticancer treatment at the time of study entry that, in the judgment of the investigator could impact the results of treatment of metastatic uveal melanoma.
• • Pregnant or nursing women. Women of childbearing potential (defined as having had a menstrual cycle within the past 12 months, and not having had a surgical procedure for sterilization) must have a negative pregnancy test (urine or serum) within 7 days of treatment with 225Ac-MTI-201.
• • Participants with uncontrolled inter-current illness including, but not limited to, ongoing or active bacterial infection, active hepatitis B/C infection requiring antiviral therapy, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
• • Immunocompromised participants may be at increased risk of toxicity. Therefore, HIV-positive participants, participants with acquired or congenital immunodeficiency conditions, those on chronic systemic corticosteroids requiring \>10 mg of prednisone or equivalent per day will be excluded from participation. (Participants with autoimmune disease who do not require corticosteroids or are maintained on ≤10 mg of prednisone or equivalent per day ARE eligible for participation; for participants with CNS metastases on steroids, exclusion criterion bullet point #2 above will apply).
• • Prior external beam radiation therapy to more than 25 percent of the bone marrow.