Exercise Effects in Multiple Sclerosis

Launched by UNIVERSITY OF REGINA · Aug 8, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring how different types of exercise can impact people living with multiple sclerosis (MS). Researchers want to understand how regular exercise might help manage symptoms, improve physical function, and affect the brain and nervous system in individuals with various forms of MS, including progressive and relapsing types. This study will be the first to compare the effects of different exercise routines on the central nervous system for those with MS.

To participate, individuals must be diagnosed with progressive MS by a neurologist and receive a doctor's approval to exercise. They should have a moderate level of motor disability, which is measured by a specific scoring system. Participants should be aged between 65 and 74 and need to meet certain criteria related to their physical activity levels. If you join the study, you'll engage in different exercise programs and help researchers learn how exercise can benefit people with MS. It's an exciting opportunity to contribute to understanding how to improve the quality of life for those living with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • diagnosis of progressive MS by a neurologist
• • physician clearance for exercise
• • a Patient-Determined Disease Steps (PDSS) score between 3 and 7 (i.e., moderate motor disability)
• • a Timed 25-Foot Walk (T25-FW) test time \> 6.0 s.
• Exclusion Criteria:
• • a baseline score \>24 on the Godin-Shephard Leisure Time Physical Activity Questionnaire (i.e., high physical activity levels)
• • absolute contraindications to TMS (e.g. history of seizure)
• • a history of any neurological conditions other than MS
• • relapse in the past three months (self-reported, neurologist confirmed)
• • psychiatric diagnosis
• • substance abuse