The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure.

Launched by EVA PONTEN · Aug 9, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how muscle structure changes over time in children with cerebral palsy (CP), a condition that affects movement due to brain injury. CP can cause tightness in muscles and problems with coordination, which may lead to the muscles becoming shorter and joints becoming stiff. Researchers want to see if a common treatment involving botulinum toxin injections, along with physical training and splinting, can improve muscle health and function. They will take small samples of muscle tissue (biopsies) from participants at different times to look for signs of muscle growth and adaptation.

Children aged 2 to 18 with cerebral palsy or acquired brain injury may be eligible to join this study, but those with progressive neurological diseases will not qualify. Participants will receive standard care, and their muscle samples will be collected before treatment starts and again after 4-6 months, 12 months, and 24 months to track changes. The findings from this trial could help develop better treatments to prevent muscle and joint problems in kids with CP.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Cerebral Palsy, Aquired Brain Injury
• Exclusion Criteria:
• • Progressive neural disease