AMT-151 in Patients With Selected Advanced Solid Tumours

Launched by MULTITUDE THERAPEUTICS INC. · Aug 10, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment called AMT-151 for patients with certain advanced cancers, including various types of ovarian, endometrial, lung, breast, and pancreatic cancers. The study aims to find out the highest dose of AMT-151 that patients can tolerate, how safe it is, and how effective it may be in treating these cancers. This is the first time AMT-151 is being tested in humans, so researchers are eager to learn how it works in the body and its potential benefits.

To participate in this trial, patients must be at least 18 years old and have a confirmed diagnosis of one of the specified advanced cancers. They should have already received treatment but may not have any remaining standard treatment options. Participants will need to agree to regular study visits and provide a tissue sample from their cancer. Throughout the trial, patients will receive close monitoring to assess their health and response to the treatment. It's important for potential participants to discuss with their doctors to see if this trial is a good fit for them.

Gender

ALL

Eligibility criteria

• Key Inclusion Criteria:
• • Patients must be willing and able to sign the Informed Consent Form, and to adhere to the study visit schedule and other protocol requirements.
• • Age ≥18 years (at the time consent is obtained).
• * Patients with the following histologically confirmed, advanced cancer diagnoses:
• • 1. Serous, endometrioid, clear-cell, or mucinous epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.
• • 2. Serous, endometrioid, or clear-cell endometrial cancer.
• • 3. Adenocarcinoma of the lung.
• • 4. Triple-negative breast cancer.
• • 5. Pancreatic ductal adenocarcinoma.
• • 6. Malignant pleural mesothelioma.
• • Patients who have undergone any number of prior systemic therapies and have radiologically or clinically determined progressive disease during or after their most recent line of therapy, and for whom no further standard therapy is available, or who are intolerable to standard therapy.
• • Patients must have at least one measurable or non-measurable lesion as per RECIST version 1.1.
• • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
• • Adequate function of bone marrow, liver, kidneys, heart.
• • Both male and female patients must agree to use effective contraceptive methods.
• • Women of child-bearing potential (WCBP) must have a negative serum pregnancy test.
• • Availability of tumour tissue sample (either an archival specimen or a fresh biopsy material) at screening.
• Key Exclusion Criteria:
• • Prior treatment with any agent targeting Folate Receptor Alpha.
• • Active central nervous system metastasis.
• • Persistent toxicities from previous systemic anti-neoplastic treatments of Grade \>1.
• • Systemic anti-neoplastic therapy within five half-lives or 21 days, whichever is shorter, prior to the first dose of the study drug.
• • Radiotherapy to lung field at a total radiation dose of \>= 20 Gy within 6 months, wide-field radiotherapy (\>30% of marrow-bearing bones) within 28 days, or focal radiation for analgesic purpose or for lytic lesions at risk of fracture within 14 days prior to the first dose of the study drug, or no recovery from side effects of such intervention.
• • Major surgery (not including placement of vascular access device or tumor biopsies) within 28 days prior to the first dose of the study drug, or no recovery from side effects of such intervention.
• • Prior allogeneic or autologous bone marrow transplantation.
• • Significant cardiac or lung disease, active or chronic ocular disorders, thromboembolic or cerebrovascular events within 6 months prior to the first dose of the study drug, acute and/or clinically significant bacterial, fungal, or viral infection.
• • Pregnant or breast-feeding females.
• • Note: Other protocol defined Inclusion/Exclusion criteria apply.