Short Against Long Antibiotic Therapy for Infected Orthopedic Sites

Launched by BALGRIST UNIVERSITY HOSPITAL · Aug 11, 2022

Keywords

ClinConnect Summary

This clinical trial, called SALATIO, is looking at how long patients with infections related to orthopedic devices (like implants or surgical grafts) should take antibiotics. There are two parts to the study: one for patients whose infected implants remain in place, comparing 6 weeks versus 12 weeks of antibiotic treatment, and another for those whose infected implants have been removed, comparing 3 weeks versus 6 weeks of antibiotics. Both parts of the trial will also allow a switch to oral antibiotics earlier in the treatment process.

To participate in this trial, you must be at least 18 years old and have an infection related to your bones or orthopedic devices. You should also be able to commit to follow-up appointments for a year after your hospital stay. However, if you have certain types of infections (like fungal or specific bacterial infections) or have had extensive prior treatments for the same infection site, you may not qualify. If you join the trial, you'll receive close monitoring and care to ensure your treatment is effective.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years on admission
• • Orthopedic bone and implant infections including musculoskeletal grafts
• • Intraoperative debridement with any surgical technique
• • 12 months of scheduled follow-up from hospitalization
• • Bacterial orthopedic infections of any nature
• • First or second episode of infection
• Exclusion Criteria:
• • Mycobacterial, fungal, nocardial, and Actinomyces infections
• • Purely soft tissue infections
• • Non-resected cancer in the infection site
• • Purely intrasynovial infections (native joint septic arthritis)
• • More than three debridements performed for infection
• • Absence of at least one surgical intraoperative debridement
• • Spine infections (investigated in another trial)10
• • Diabetic foot infections (investigated in another trial)7
• • Documented endocarditis according to the Duke criteria
• • At least 2 prior infection episodes at the actual infection site