Vellore Typhoid Vaccine Impact Trial

Launched by CHRISTIAN MEDICAL COLLEGE, VELLORE, INDIA · Aug 8, 2022

Keywords

ClinConnect Summary

The Vellore Typhoid Vaccine Impact Trial is a study designed to see how well a new typhoid vaccine called TyphiBEV works in reducing the number of typhoid fever cases in a busy city in South India. Typhoid fever is a serious illness that can spread easily, especially in areas with poor sanitation. This trial is open to both adults and children aged 1 to 29 years who live in the study area and are willing to participate, with permission from a parent or guardian if they are under 18.

Participants in the trial will receive the vaccine and will be monitored for any cases of typhoid fever over the next two years. To be eligible, individuals must not have had a typhoid vaccine recently or have any medical issues that would prevent them from following the study requirements. This study is currently recruiting, and it aims to provide important information on how effective this vaccine is in preventing typhoid fever in communities that are heavily affected by the disease. If you're interested in participating or want more information, please reach out to the study team.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Consent
• • For adults, 18 years and over - they must be willing and competent to provide informed consent
• • For those aged under 18 years, the parent/guardian is willing and competent to provide informed consent, and if the participant is 11 to 18 years of age, informed assent will also be sought,
• * Age:
• • Between 1 and 30 years (i.e., up to 29 years 364 days) at time of recruitment into the surveillance
• • Currently living within the study catchment area with no plans to leave the study area in the next 24 months
• Exclusion Criteria:
• • For fever surveillance
• • o Medical reasons that prevent the participant from complying with study requirements including follow up and testing during illness
• • For vaccination
• • Has received a typhoid vaccine in the previous three years
• • Is known to have an allergy to any vaccine component
• • Nursing mothers, Pregnancy or planning pregnancy around vaccination
• • Receipt of any other vaccine in the past 30 days (temporary exclusion)
• • Febrile illness in the 24 hours before vaccination (temporary exclusion)