PlacEntal Acute Atherosis RefLecting Subclinical Atherosclerosis

Launched by MAASTRICHT UNIVERSITY MEDICAL CENTER · Aug 11, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how pregnancy affects women’s heart health, especially in complicated pregnancies like those with pre-eclampsia or HELLP syndrome. Researchers want to understand how these conditions might change a woman's heart and blood vessel function during pregnancy and whether these changes last after giving birth. This information could help identify ways to improve heart health for women in the future.

To participate in the study, women must be at least 18 years old. The trial is looking for two groups of participants: those who have a complicated pregnancy (like pre-eclampsia) and those with a normal, healthy pregnancy. Participants will undergo tests to evaluate their heart function, and they can expect to be informed about their results and how they may relate to their overall health. The study is currently recruiting, so interested women should check if they meet the eligibility criteria.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women aged ≥ 18 years
• • Controls: Women with an uncomplicated pregnancy at the moment of inclusion (i.e no foetal or maternal placental complications, such as pregnancy induced hypertension, preeclampsia or HELLP-syndrome, or small for gestational birth infancies)
• • Cases: Women diagnosed with a preeclamptic pregnancy at the moment of inclusion
• Exclusion Criteria:
• • • Women who do not want to be informed about the results of the tests, or women who do not want their general practitioner and specialist(s) to be informed about the test results
• • Allergy or intolerance to glyceryl trinitrate, betablockers or iodinated contrast media.
• • Controls: Pre-existing chronic hypertension treated with antihypertensive medication or autoimmune disorder.