Relationship of Inflammation and Pulmonary Function to Fungal Translocation in HIV

Launched by UNIVERSITY OF PITTSBURGH · Aug 15, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how inflammation and fungal infections affect lung health in people living with HIV. Researchers want to understand how fungi from the gut might be linked to lung problems and inflammation, especially in those with chronic obstructive pulmonary disease (COPD). COPD is a serious lung condition that is common and can be challenging to treat. The study aims to explore the connections between gut health and lung function, which may help develop better treatments for those with both HIV and lung issues.

To participate in this trial, individuals need to be between 18 and 80 years old, be HIV positive, and have been on effective HIV treatment for at least six months. Participants will undergo tests to measure their lung function and may be asked about their health history. It’s important to note that those with certain recent surgeries, specific lung diseases, or other health conditions may not be eligible. By joining this study, participants could contribute to important research that aims to improve understanding and treatment for lung disease in the context of HIV.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 to 80
• • HIV positive
• • Virally-suppressed on ART for at least 6 months
• • subjects enrolled in Dr. Morris's HLRC Studies STUDY20020151, STUDY19080258, STUDY19060243, STUDY19070181, STUDY19070181, STUDY19050326 OR subjects being seen at the HIV/PACT clinics.
• Exclusion Criteria:
• • Contraindication to pulmonary function testing (i.e., abdominal or cataract surgery within 3 months, recent myocardial infarction, etc.).
• • individuals with clinical or radiographic evidence of another significant pulmonary diagnosis (e.g. interstitial lung disease, active asthma)
• • inflammatory bowel disease
• • pregnancy
• • use of antibiotics in the prior 2 weeks
• • immunomodulators in the prior 6 months
• • unable to perform any study procedures.