Perioperative Analgesia Modes in Minimally Invasive Esophagectomy

Launched by CANCER INSTITUTE AND HOSPITAL, CHINESE ACADEMY OF MEDICAL SCIENCES · Aug 15, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at different ways to manage pain for patients undergoing minimally invasive surgery to treat esophageal cancer. The goal is to find out which pain relief methods work best and are the safest during and after the surgery. If you are between the ages of 18 and 75 and are scheduled for this type of surgery, you might be eligible to participate. However, there are some health conditions that could exclude you from the trial, such as recent serious lung issues, a history of certain heart problems, or if you are a heavy drinker or regularly use strong pain medications.

If you choose to take part, you’ll receive one of several pain management methods during your surgery, and we’ll closely monitor how well they work and any side effects you might experience. Participation in this trial could help improve pain management for future patients undergoing similar surgeries. Remember, your safety and well-being are our top priorities, and you’ll be able to ask questions and get support throughout the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18-75 years;
• • Patients underwent laparoscopic and thoracoscopic or robotic-assisted minimally invasive esophagectomy ;
• • Informed consent.
• Exclusion Criteria:
• • Has a history of cholecystitis or urolithiasis within 3 months;
• • Has a history of atherothrombosis (peripheral arterial disease), stroke, myocardial infarction;
• • With lung diseases, such as pneumonia, atelectasis, emphysema, pulmonary bullae, etc;
• • Preoperative cardiac function grade ≥ III or coronary artery stenosis;
• • Preoperative indwelling of a thoracic drainage tube;
• • Long-term heavy drinker(heavy drinking was defined as follows: for men, consuming more than 4 drinks on any day or more than 14 drinks per week; For women, consuming more than 3 drinks on any day or more than 7 drinks per week);
• • Opioid-tolerant patients(defined as those who have been taking, for a week or longer, at least 60 mg of morphine daily, or at least 30 mg of oral oxycodone daily, or at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid);
• • With painful skin complications, such as rashes and blisters;
• • Conversion to open surgery;
• • The postoperative ventilation function was limited, or the duration of endotracheal intubation was more than 24h.