How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.
Launched by EVA PONTEN · Aug 16, 2022
Trial Information
Current as of July 24, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying how muscles are affected in children with cerebral palsy (CP) and those who have had an acquired brain injury (ABI). Researchers want to understand why the muscles in these children become weaker, shorter, and stiffer over time, which can lead to difficulties with movement and joint problems. To do this, they will collect muscle samples during necessary orthopedic surgeries from children with CP, ABI, and from typically developing children who are having surgery for other reasons. They will examine these samples to look for signs of inflammation and changes in muscle growth, which may help develop better treatments to protect muscle and joint health.
Children and adolescents aged 2 to 18 who are undergoing orthopedic surgery and have either CP or ABI may be eligible to participate. Typically developing children undergoing similar surgeries can also join as a comparison group. Participants can expect to provide muscle and blood samples during their surgery, and the study aims to find new insights into how to prevent problems like muscle stiffness and joint dislocation. The goal is to ultimately improve the quality of life for children with CP and ABI.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Children and adolescents undergoing clinically needed orthopaedic surgery
- • with Cerebral Palsy or Acquired Brain Injury
- • Typically developed children and adolescents (control)
- Exclusion Criteria:
- • for CP/ABI: Progressive neurological disease, other metabolic or muscle disease
- • for TD (Control): Cerebral Palsy, Acquired Brain injury, other metabolic or muscle diseases
About Eva Ponten
Eva Ponten is a dedicated clinical trial sponsor focused on advancing medical research and improving patient outcomes through innovative therapeutic solutions. With a commitment to rigorous scientific standards and ethical practices, Eva Ponten collaborates with leading research institutions and healthcare professionals to conduct high-quality clinical trials. The organization emphasizes transparency, safety, and integrity in all its endeavors, aiming to contribute significantly to the development of new treatments that address unmet medical needs. Through strategic partnerships and a patient-centered approach, Eva Ponten strives to accelerate the delivery of groundbreaking therapies to the market.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Stockholm, , Sweden
Patients applied
Trial Officials
Eva M Pontén, MD PhD
Principal Investigator
Karolinska Institutet
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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