How Are the Muscles Affected in Cerebral Palsy? A Study of Muscle Biopsies Taken During Orthopaedic Surgery.

Launched by EVA PONTEN · Aug 16, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how muscles are affected in children with cerebral palsy (CP) and those who have had an acquired brain injury (ABI). Researchers want to understand why the muscles in these children become weaker, shorter, and stiffer over time, which can lead to difficulties with movement and joint problems. To do this, they will collect muscle samples during necessary orthopedic surgeries from children with CP, ABI, and from typically developing children who are having surgery for other reasons. They will examine these samples to look for signs of inflammation and changes in muscle growth, which may help develop better treatments to protect muscle and joint health.

Children and adolescents aged 2 to 18 who are undergoing orthopedic surgery and have either CP or ABI may be eligible to participate. Typically developing children undergoing similar surgeries can also join as a comparison group. Participants can expect to provide muscle and blood samples during their surgery, and the study aims to find new insights into how to prevent problems like muscle stiffness and joint dislocation. The goal is to ultimately improve the quality of life for children with CP and ABI.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children and adolescents undergoing clinically needed orthopaedic surgery
• • with Cerebral Palsy or Acquired Brain Injury
• • Typically developed children and adolescents (control)
• Exclusion Criteria:
• • for CP/ABI: Progressive neurological disease, other metabolic or muscle disease
• • for TD (Control): Cerebral Palsy, Acquired Brain injury, other metabolic or muscle diseases