Broccoli Sprouts for Mild Ulcerative Colitis

Launched by UNIVERSITY OF MICHIGAN · Aug 17, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at whether eating broccoli sprouts can help people with mild ulcerative colitis, a condition that causes inflammation in the digestive tract. The researchers want to find out how much broccoli sprouts a person needs to eat to increase a beneficial compound called sulforaphane in their body and to see if it can lower inflammation levels. This study is a small step to prepare for a larger trial in the future.

To join the study, participants should be between the ages of 65 and 74 and have a confirmed diagnosis of ulcerative colitis. They should also be stable on their current medications for at least two weeks and not be on a special diet or using tube feeds. Participants will be asked to fill out surveys about their diet and bowel symptoms. If you’re interested, it’s important to know that you won’t be able to change your medications during the study, and there are some restrictions on what medications or diets you can be on.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Documented endoscopic diagnosis of ulcerative colitis
• • Currently being treated with a stable dose of 5-ASAs, steroids, or any other medication approved for ulcerative colitis
• • If on 5-ASA, no dose changes within 2 weeks before the Day 0 visit
• • If on steroids, prednisone dose not more than 20 mg daily and entocort not more than 9 mg daily, with no dose changes within 2 weeks before the Day 0 visit
• • All other medications require a stable dose for at least 8 weeks prior to enrollment.
• • No dose changes to any IBD medication anticipated for the duration of the study
• • Body Mass Index (BMI) values 18.5-40 kg/m2
• • Not on total parenteral nutrition (TPN) or receiving tube feeds.
• • Ability to understand the study procedures, benefits and risks, and sign a written informed consent document.
• • Able to fill out questionnaires regarding dietary intakes, bowel symptoms, and study experience
• Exclusion Criteria:
• • Taking Non-steroidal anti-inflammatory drugs (NSAIDs)
• • Following a medically-prescribed diet, on Total parenteral nutrition (TPN), or tube feeds
• • Newly diagnosed (within past month), or uncontrolled diabetes or cardiovascular disease
• • Antibiotics in the previous 2 weeks
• • Consumption of more than 5 ½ cups of servings/day of fruits and vegetables as assessed by the National Cancer Institute (NCI) Diet History Questionaire III online Food Questionnaire.
• • A known allergy or sensitivity to cruciferous vegetables like arugula, bok choy, broccoli, cabbage, cauliflower, or collard greens