AI Driven National Platform for CT cOronary Angiography for clinicaL and industriaL applicatiOns Registry

Launched by NATIONAL HEART CENTRE SINGAPORE · Aug 18, 2022

Keywords

ClinConnect Summary

This clinical trial, called APOLLO, is studying a new platform that uses artificial intelligence (AI) to help doctors better understand and manage coronary artery disease (CAD). The goal is to create a system that can automatically process CT scans of the heart, which helps identify issues like narrowed arteries and plaque buildup. This "one-stop" platform aims to make diagnosing and treating heart conditions easier and more efficient, and it may also help predict how well certain medications will work for patients.

To participate in the trial, individuals need to be at least 21 years old and must provide their consent to take part. They also need to have a medical reason for needing a CT scan of their heart. However, certain people are not eligible, such as those with specific heart conditions, pregnant women, and those with serious non-heart-related illnesses. Participants can expect to undergo a CT scan and have their results processed through this new AI platform, contributing to important research that could improve heart care for everyone.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥21 years old
• • 2. Signed informed consent
• • 3. Clinically indicated for evaluation by CTCA
• Exclusion Criteria:
• • 1. Individuals unable to provide informed consent
• • 2. Known complex congenital heart disease
• • 3. Planned invasive angiography for reasons other than CAD
• • 4. Non-cardiac illness with life expectancy \< 2 years
• • 5. Pregnancy
• • 6. Concomitant participation in another clinical trial in which subject is subject to investigational drug or device
• • 7. Cardiac event and/or coronary revascularization (percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG) and/or valvular repair/replacement prior to CTCA
• • 8. Glomerular Filtration Rate ≤ 30mL/min
• • 9. Known allergy to iodinated contrast agent
• • 10. Contraindications to beta blockers or nitroglycerin or adenosine