Uterine Microbiome in Recurrent Pregnancy Loss

Launched by MỸ ĐỨC HOSPITAL · Aug 19, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how the bacteria in the uterus and vagina, known as the microbiome, may affect women's ability to have successful pregnancies. Researchers believe that women who have experienced recurrent pregnancy loss (losing two or more pregnancies) may have a different makeup of these bacteria compared to women who have had healthy pregnancies. By understanding these differences, the study aims to find out if the microbiome plays a role in pregnancy outcomes.

To participate in this study, women aged 18 to 38 who have had recurrent pregnancy loss or those who have had healthy pregnancies (with at least one live birth) may be eligible. Participants will have their microbiome analyzed, and they must agree to follow certain guidelines, like having regular menstrual cycles and not using certain medications before the study. The trial is currently recruiting, and participants can expect to contribute to important research that could help improve pregnancy outcomes for women in the future.

Gender

FEMALE

Eligibility criteria

• • 1. Recurrent pregnancy loss patients
• Inclusion Criteria:
• • 18-38 years old
• • Having a regular menstrual cycle, from 25 to 35 days
• • Having ≥ 2 recurrent pregnancy loss and
• • Couples with normal karyotype results
• • Having no condition causing pregnancy loss such as antiphospholipid syndrome, abnormal thyroid function.
• • Agree to participate in the study
• Exclusion Criteria:
• • Irregular menstrual cycle
• • Having uterine abnormalities (e.g., adenomyosis, intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp, submucosal fibroid)
• • Using intrauterine device within the last 3 months
• • Using antibiotic/vaginal pessary/contraceptive pills within 2 weeks
• • Having sexual intercourse within 48 hours
• • 2. Healthy control patients
• Inclusion Criteria:
• • 18-38 years old
• • Having a regular menstrual cycle, from 25 to 35 days
• • No history of pregnancy loss
• • Having 1 or more live birth, with the youngest child ≥ 6 months old
• • Agree to participate in the study
• Exclusion Criteria:
• • Irregular menstrual cycle
• • Having uterine abnormalities (e.g., adenomyosis, intrauterine adhesions, unicornuate/ bicornuate/ arcuate uterus; unremoved hydrosalpinx, endometrial polyp, submucosal fibroid)
• • Using intrauterine device within the last 3 months
• • Using antibiotic/vaginal pessary/contraceptive pills within 2 weeks
• • Having sexual intercourse within 48 hours