Oxygen Consumption and Sevoflurane Uptake Based on Physiological Dead Space Estimation

Launched by FUNDACIÓN PÚBLICA ANDALUZA PARA LA GESTIÓN DE LA INVESTIGACIÓN EN SEVILLA · Aug 22, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how well the amount of oxygen and a specific anesthetic called sevoflurane are used in patients undergoing robotic prostate surgery. The researchers want to see if their method for calculating how much of these gases is needed, based on certain measurements, matches what is actually used by the body during surgery. All participants will be supported with a special ventilation technique to help keep their lungs open during the procedure.

To participate in this study, you need to be an adult (18 years or older) who is scheduled for robotic prostate surgery at the research site and can provide written consent. However, if you have certain health conditions, such as severe heart or lung issues, or if you have participated in another study recently, you may not be eligible. If you qualify and choose to join, you can expect to receive close monitoring during your surgery to ensure your safety and comfort.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult subjects (≥ 18 years) scheduled for robotic prostatic surgery at the investigators´ institution
• • Written informed consent
• Exclusion Criteria:
• • Participation in another interventional study
• • Participants unable to understand the information contained in the informed consent
• • American Society of Anesthesiologists (ASA) classification grade = IV
• • Patient in dialysis
• • Chronic obstructive pulmonary disease (COPD) grade Global Initiative for Chronic Obstructive Lung Disease(GOLD) \> 2
• • Functional vital capacity \< 60% or \> 120% of the predicted
• • Body mass index (BMI) \> 35 kg/m2
• • Relation arterial pressure of oxygen (PaO2)/FiO2 \<200 mmHg in the baseline sample
• • Presence of mechanical ventilation in the 72 hours prior to enrollment
• • New York Heart Association (NYHA) functional class ≥ 3
• • Clinically suspected heart failure
• • Diagnosis or suspicion of intracranial hypertension
• • Presence of pneumothorax or giant bullae on preoperative imaging tests
• • Use of Continuous Positive Airway Pressure (CPAP).