Effect of Remimazolam and Propofol on Postoperative Delirium

Launched by INJE UNIVERSITY · Aug 23, 2022

Keywords

ClinConnect Summary

This clinical trial is studying two different medications, remimazolam and propofol, to see which one is better at reducing the risk of postoperative delirium in elderly patients after orthopedic surgery, such as operations on hip or knee fractures. Postoperative delirium is a condition that can cause confusion and changes in awareness after surgery, and the researchers want to find out if one of these medications can help prevent it.

To participate in the trial, patients need to be elderly individuals who are scheduled for hip or knee surgery and have a body mass index (BMI) over 30. However, certain individuals are not eligible, including those with serious liver or kidney problems, those who can't be safely taken off a breathing machine after surgery, or those with a history of certain mental health issues. Participants can expect to receive either remimazolam or propofol during their surgery and will be monitored closely to see how well they recover and whether they experience any delirium afterward. This trial is important because it could help improve recovery outcomes for older patients undergoing surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • elderly patients undergoing hip or knee arthroplasty under general anesthesia.
• • body mass index \>30 kg/m2
• Exclusion Criteria:
• • moderate to severe liver dysfunction
• • moderate to severe renal dysfunction
• • unable to extubate in the operation room after operation
• • benzodiazepine dependence
• • sensitivity to anesthetic drugs used for study (Benzodiazepines, Propofol, Remifentanil, Fentanyl citrate, Rocuronium bromide, Sugammadex, Flumazenil)
• • acute angle glaucoma
• • received (benzodiazepine, antianxiety drugs, antidepressant, antipsychotic drugs) within 24 hours.
• • acute psychotic depression
• • history stroke or cerebrovascular disease