Conversion of Labor Analgesia for Intrapartum Cesarean Delivery: DPE v CSE v Epidural
Launched by MAYO CLINIC · Aug 22, 2022
Trial Information
Current as of October 15, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
This study looks at labor pain relief techniques used when a cesarean delivery becomes necessary during labor. It compares three neuraxial block methods—Dural Puncture Epidural (DPE), Combined Spinal-Epidural (CSE), and traditional Epidural—and checks if the DPE or CSE methods help more often to switch to surgical anesthesia successfully at the time of cesarean. It’s a retrospective observational study, using past medical records from Mayo Clinic (2017–2021) and BC Women’s Hospital (2022). The main outcome is whether the patient needed another form of anesthesia during the cesarean (such as a spinal, a second epidural, or general anesthesia). Researchers will collect details like needle size, timing, number of top-ups, medications used, urgency of delivery, airway events, and procedure length, along with basic maternal and baby information.
Who can be part of this study? It includes women with neuraxial labor anesthesia (epidural, CSE, or DPE) who have an intrapartum cesarean delivery and a singleton pregnancy. Exclusions include cases where no local anesthetic was given for the cesarean (in emergencies) or cases of inadvertent dural puncture. The trial plans to enroll about 1,500 participants and is currently enrolling by invitation. It is not a randomized trial and involves no direct patient contact or new treatment; researchers will use existing medical records. The study is led by Mayo Clinic with collaboration from the University of British Columbia, and results may help inform future choices about labor analgesia for cesarean delivery.
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • 1. Women with neuraxial labor analgesia (CSE, DPE, or Epidural) who have an intrapartum cesarean delivery
- • 2. Singleton gestation
- Exclusion Criteria:
- • 1. No local anesthetic given in epidural for cesarean delivery (in emergency situation)
- • 2. Inadvertent dural puncture
About Mayo Clinic
Mayo Clinic is a renowned nonprofit medical practice and research institution dedicated to providing comprehensive healthcare and advancing medical knowledge through innovative research and education. With a commitment to patient-centered care, Mayo Clinic conducts numerous clinical trials aimed at exploring new therapies and improving treatment outcomes across various disciplines. Leveraging a multidisciplinary approach, the institution collaborates with leading experts and cutting-edge technology to ensure rigorous scientific standards and ethical practices in all its research endeavors. Through its trials, Mayo Clinic seeks to translate breakthroughs in science into tangible benefits for patients, fostering advancements in medicine that enhance health and quality of life.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Rochester, Minnesota, United States
Vancouver, British Columbia, Canada
Patients applied
Trial Officials
Emily Sharpe, MD
Principal Investigator
Mayo Clinic
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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