Proximal Gastrectomy Anterior Anastomosis With Pyloroplasty Versus Esophagogastric Anastomosis for Gastric Cancer

Launched by NANCHONG CENTRAL HOSPITAL · Aug 23, 2022

Keywords

ClinConnect Summary

This clinical trial is studying two different surgical methods for treating gastric cancer, specifically a type called proximal gastric adenocarcinoma. The researchers want to compare the outcomes of two procedures: one that connects the stomach to the small intestine with a technique called pyloroplasty and another that connects the esophagus directly to the stomach. They are interested in how these surgeries affect patients in terms of symptoms related to gastroesophageal reflux disease, quality of life after surgery, and both short-term and long-term health outcomes.

To participate in this trial, you need to have a confirmed diagnosis of stomach cancer at certain stages (T1-T4), be generally healthy enough to undergo surgery (with a performance status of 0 or 1), and have good organ function. However, if you have cancer that has spread to distant parts of the body, have significant invasion of the esophagus, or have received prior chemotherapy or radiation for any other cancers, you may not be eligible. If you join the study, you can expect to receive one of the two surgical treatments and be followed up to assess your recovery and overall health. This trial is currently recruiting participants aged 65 to 74, and it's open to all genders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.
• • 2. Eastern Cooperative Oncology Group performance status of 0 or 1.
• • 3. Adequate organ function.
• Exclusion Criteria:
• • 1. Patients had distant metastasis.
• • 2. oesophageal invasion of more than 3 cm.
• • 3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.
• • 4. Previous chemotherapy or radiation therapy for any other malignancies.