Effect of Imipenem and Meropenem on the Digestive Microbiota and the Emergence and Carriage of Multidrug-resistant Bacteria

Launched by FONDATION HÔPITAL SAINT-JOSEPH · Aug 23, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how two antibiotics, imipenem and meropenem, affect the gut bacteria of patients with infections caused by certain resistant bacteria called Enterobacteriaceae. These bacteria have become a significant health concern because they are hard to treat and can lead to serious complications. The goal of the study is to compare how these two antibiotics impact the diversity of bacteria in the digestive system and the emergence of multidrug-resistant bacteria, which are bacteria that have become resistant to multiple treatments.

To take part in this trial, participants must be at least 18 years old, currently hospitalized in the intensive care unit at one of the participating hospitals, and require treatment with either imipenem or meropenem for their infection. Participants will be monitored to see how their gut bacteria respond to the antibiotic they receive. It’s important to note that individuals with allergies to carbapenems, pregnant or breastfeeding women, and certain other groups may not be eligible for this study. This research could help improve our understanding of how to use antibiotics more effectively while minimizing the risk of developing resistant bacteria.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient ≥ 18 years old
• • Patient hospitalized in the intensive care unit of the Groupe Hospitalier Paris Saint-Joseph or the Avicenne Hospital
• • Patient with an infection requiring probabilistic or documented treatment with a carbapenem (imipenem or meropenem)
• • French speaking patient
• • Patient or relative able to give his or her non-objection
• Exclusion Criteria:
• • Patients with a carbapenem allergy
• • Pregnant or breastfeeding woman
• • Patient under guardianship or curatorship
• • Patient deprived of liberty
• • Patient under court protection