A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Launched by CELGENE · Aug 25, 2022
Trial Information
Current as of July 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating a new treatment combination for patients with relapsed or refractory multiple myeloma (RRMM), which means their cancer has returned or did not respond to previous therapies. The study is comparing two treatment groups: one group will receive mezigdomide, bortezomib, and dexamethasone (called MEZIVd), while the other group will receive pomalidomide, bortezomib, and dexamethasone (called PVd). The goal is to see which combination is more effective and safer for patients who have already tried one to three previous treatments and have experienced some level of benefit from those treatments.
To be eligible for this study, participants must have a confirmed diagnosis of multiple myeloma and measurable disease, meaning that the disease can be tracked with specific tests. They should have received one to three prior therapies and should have had at least a minimal response to one of those treatments. Patients who have had recent progression during or shortly after certain treatments or those who have previously used the drugs being tested may not qualify. If you choose to participate, you will be closely monitored throughout the study, and your health will be regularly assessed to evaluate how well the treatment is working.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- • - Participant has documented diagnosis of MM and measurable disease, defined as any of the following:.
- • i) M-protein ≥ 0.5 grams per deciliter (g/dL) by serum protein electrophoresis (sPEP) or.
- • ii) M-protein ≥ 200 milligrams (mg) per 24-hour urine collection by urine protein electrophoresis (uPEP).
- • iii) For participants without measurable disease in sPEP or uPEP: serum free light chain (sFLC) levels \> 100 mg/L (10 mg/dL) involved light chain and an abnormal kappa/lambda FLC ratio.
- • Participants received 1 to 3 prior lines of antimyeloma therapy.
- • Participants achieved minimal response \[MR\] or better to at least 1 prior antimyeloma therapy.
- • Exclusion Criteria
- • - Participant has had progression during treatment or within 60 days of the last dose of a proteasome inhibitor, except as noted below:.
- • i) Subjects who progressed while being treated with, or within 60 days of last dose of bortezomib maintenance given once every 2 weeks (or less frequently) are not excluded.
- • ii) Participants who progressed while being treated with ixazomib monotherapy maintenance ≥ 6 months prior to the time of starting study treatment are not excluded.
- • For participants with prior treatment of a bortezomib containing regimen, the best response achieved was not a minimal response (MR) or better, or participant discontinued bortezomib due to toxicity.
- • Participant has had prior treatment with mezigdomide or pomalidomide.
- • Other protocol-defined Inclusion/Exclusion criteria apply.
About Celgene
Celgene, now a part of Bristol Myers Squibb, is a global biopharmaceutical company dedicated to advancing innovative therapies for patients with cancer and other serious diseases. With a strong emphasis on research and development, Celgene focuses on discovering and delivering transformative medicines that address unmet medical needs. The company is committed to enhancing patient outcomes through rigorous clinical trials, cutting-edge science, and collaboration with healthcare professionals, ultimately striving to improve the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kansas City, Kansas, United States
Ann Arbor, Michigan, United States
Iowa City, Iowa, United States
Detroit, Michigan, United States
Chicago, Illinois, United States
Baltimore, Maryland, United States
Liverpool, New South Wales, Australia
Madrid, , Spain
Rochester, New York, United States
New Orleans, Louisiana, United States
San Diego, California, United States
Durham, North Carolina, United States
Cleveland, Ohio, United States
Box Hill, Victoria, Australia
Boston, Massachusetts, United States
Murcia, , Spain
Cleveland, Ohio, United States
Seattle, Washington, United States
New Haven, Connecticut, United States
London, , United Kingdom
Nedlands, Western Australia, Australia
Houston, Texas, United States
Norfolk, Virginia, United States
Buffalo, New York, United States
Madison, Wisconsin, United States
Seattle, Washington, United States
Salt Lake City, Utah, United States
Melbourne, Victoria, Australia
Beijing, Beijing, China
Minneapolis, Minnesota, United States
Vancouver, Washington, United States
Antwerpen, , Belgium
Tuebingen, , Germany
Seoul, , Korea, Republic Of
Westwood, Kansas, United States
Barcelona, , Spain
Shijiazhuang, Hebei, China
Leicester, Leicestershire, United Kingdom
London, , United Kingdom
Kashiwa, Chiba, Japan
Sapporo, Hokkaido, Japan
Melbourne, Victoria, Australia
Waratah, New South Wales, Australia
Cincinnati, Ohio, United States
Athens, Georgia, United States
Cambridge, Cambridgeshire, United Kingdom
Kiel, , Germany
Bonn, Nordrhein Westfalen, Germany
Nantes, , France
Albuquerque, New Mexico, United States
Wien, , Austria
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Busan, , Korea, Republic Of
Auckland, , New Zealand
Tuebingen, , Germany
Tokyo, , Japan
Bonn, , Germany
Marburg, , Germany
Seoul, , Korea, Republic Of
Paris, , France
Wels, , Austria
Pavia, , Italy
Garden City, Kansas, United States
Guangzhou, , China
Linz, , Austria
Guangzhou, Guangdong, China
Chiba, , Japan
Seoul, , Korea, Republic Of
Changsha, Hunan, China
Madurai, Tamil Nadu, India
Allentown, Pennsylvania, United States
Kumamoto, , Japan
Buenos Aires, , Argentina
Fukuoka, , Japan
Melbourne, , Australia
Newcastle Upon Tyne, , United Kingdom
Bucharest, , Romania
Aachen, , Germany
Lille, , France
Wuhan, Hubei, China
Kamakura, Kanagawa, Japan
Beijing, , China
Wuxi, Jiangsu, China
Shenyang, Liaoning, China
Marbella, Málaga, Spain
Nanjing, Jiangsu, China
Marbella, , Spain
Beijing, Beijing, China
Seongnam, , Korea, Republic Of
Cáceres, , Spain
Shenzhen, Guangdong, China
Ann Arbor, Michigan, United States
Tianjin, Tianjin, China
Bamberg, , Germany
Wroclaw, , Poland
Roanoke, Virginia, United States
Saint Petersburg, Florida, United States
Tokyo, , Japan
Iasi, , Romania
Cáceres, , Spain
Changsha, Hunan, China
Busan, , Korea, Republic Of
Roma, , Italy
Hattiesburg, Mississippi, United States
Linhai, Zhejiang, China
Shijiazhuang, , China
Luoyang, Henan, China
Prague, , Czechia
Stoke On Trent, , United Kingdom
Seoul, , Korea, Republic Of
Hattiesburg, Mississippi, United States
Bronx, New York, United States
Puducherry, , India
Istanbul, , Turkey
Xiamen, Fujian, China
Braga, , Portugal
Birtinya, Queensland, Australia
Greenfield Park, Quebec, Canada
Fredericksburg, Virginia, United States
Kunming, Yunnan, China
Ningbo, Zhejiang, China
Tel Aviv, , Israel
Nanjing, Jiangsu, China
Gent, Oost Vlaanderen, Belgium
Dunedin, Otago, New Zealand
Athens, Georgia, United States
Limoges, , France
Xi'an, Shaanxi, China
London, London, City Of, United Kingdom
Qingdao, Shandong, China
Truro, England, United Kingdom
Barnet, , United Kingdom
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
West Palm Beach, Florida, United States
Farmington, Connecticut, United States
Katowice, , Poland
Porto, , Portugal
Koshigaya, Saitama, Japan
Athens, , Greece
San Antonio, Texas, United States
Zhengzhou, Henan, China
Seongnam, Kyǒnggi Do, Korea, Republic Of
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Fort Myers, Florida, United States
St. Pölten, , Austria
Los Alamitos, California, United States
Marietta, Georgia, United States
East Brunswick, New Jersey, United States
Fukuoka, , Japan
San Antonio, Texas, United States
Taiyuan, Shanxi, China
Warsaw, , Poland
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Jaú, São Paulo, Brazil
St. Pölten, , Austria
Mayfield Heights, Ohio, United States
Ramat Gan, Hamerkaz, Israel
York, Pennsylvania, United States
Kfar Saba, Hamerkaz, Israel
Tamarac, Florida, United States
Athens, , Greece
Ludhiana, , India
Pittsburgh, Pennsylvania, United States
Viedma, Río Negro, Argentina
Thessaloniki, Thessaloníki, Greece
Nantes, , France
Hamburg, , Germany
Praha, , Czechia
Palma, , Spain
Tucson, Arizona, United States
Brno, Brno Město, Czechia
Tauranga, Bay Of Plenty, New Zealand
Torun, Kujawsko Pomorskie, Poland
Haifa, Hatsafon, Israel
Xi'an, Shaanxi, China
Ramat Gan, Hamerkaz, Israel
Strasbourg, Alsace, France
Kiel, Schleswig Holstein, Germany
Helsinki, , Finland
Lille, Nord, France
Athens, Attikí, Greece
Athens, Attikí, Greece
Catania, Sicilia, Italy
Shiwa Gun Yahaba Cho, Iwate, Japan
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Tel Aviv, Tell Abīb, Israel
Palma, Balears [Baleares], Spain
Barcelona, Catalunya [Cataluña], Spain
Madrid, Madrid, Comunidad De, Spain
Helsinki, Uusimaa, Finland
Paris, île De France, France
Lisbon, , Portugal
Melbourne, Victoria, Australia
Quebec City, Quebec, Canada
Ankara, , Turkey
Seoul, Seodaemun Gu, Korea, Republic Of
Porto Alegre, Rio Grande Do Sul, Brazil
Cáceres, Extremadura, Spain
Samsun, , Turkey
Fayetteville, Arkansas, United States
Spokane, Washington, United States
Cordoba, Córdoba, Argentina
Santa Fe, , Argentina
Krems An Der Donau, , Austria
Leoben, , Austria
Greenfield Park, Quebec, Canada
Xiamen, Fujian, China
Nanning, Guangxi, China
Clermont Ferrand, , France
Rennes Cedex 02, , France
Paris, île De France, France
Hwasun, , Korea, Republic Of
Seongnam, , Korea, Republic Of
Chorzów, , Poland
Gdansk, , Poland
Lublin, , Poland
Barcelona, Catalunya [Cataluña], Spain
Ankara, , Turkey
Istanbul, , Turkey
İzmir, , Turkey
Kayseri, , Turkey
Samsun, , Turkey
Belagavi, Karnataka, India
Jackson, Mississippi, United States
Limerick, , Ireland
Warsaw, Mazowieckie, Poland
Warsaw, Mazowieckie, Poland
Palma, Balears [Baleares], Spain
Marbella, Málaga, Spain
Hwasun, Jeonranamdo, Korea, Republic Of
Cork, , Ireland
Lake Success, New York, United States
Germantown, Tennessee, United States
Viedma, Río Negro, Argentina
Rosario, Santa Fe, Argentina
Buenos Aires, , Argentina
Buenos Aires, , Argentina
Box Hill, Victoria, Australia
Gent, Oost Vlaanderen, Belgium
Quebec City, Quebec, Canada
Beijing, Beijing, China
Shenzhen, Guangdong, China
Nanjing, Jiangsu, China
Kunming, Yunnan, China
Shijiazhuang, , China
Kuopio, Pohjois Savo, Finland
Strasbourg, Alsace, France
Pessac, Aquitaine, France
Lyon Cedex 08, Rhône Alpes, France
Nîmes, , France
Tours, , France
Rome, Roma, Italy
Torun, Kujawsko Pomorskie, Poland
Palma, Illes Balears, Spain
Barcelona, , Spain
Truro, England, United Kingdom
Stoke On Trent, , United Kingdom
Barcelona, Catalunya [Cataluña], Spain
Santa Fe, , Argentina
Seoul, Seoul Teukbyeolsi [Seoul], Korea, Republic Of
Pessac, Aquitaine, France
York, Pennsylvania, United States
Clermont Ferrand, , France
Nagaizumi Cho,Sunto Gun, Shizuoka, Japan
New York, New York, United States
Saint Louis, Missouri, United States
Catania, Sicilia, Italy
Bologna, , Italy
Kuopio, Pohjois Savo, Finland
Beijing City, Beijing, China
Lake Success, New York, United States
Lyon Cedex08, Rhône Alpes, France
Vienna, Wien, Austria
West Hollywood, California, United States
Nîmes, Gard, France
Williamsville, New York, United States
Montreal, Quebec, Canada
Nîmes, Gard, France
Lyon Cedex08, Rhône Alpes, France
Tours, , France
Liverpool, New South Wales, Australia
Nowra, New South Wales, Australia
Waratah, New South Wales, Australia
Melbourne, Victoria, Australia
Nedlands, Western Australia, Australia
Lyon, Rhône Alpes, France
Bologna, , Italy
Lisbon, Lisboa, Portugal
Słupsk, Pomorskie, Poland
Shenyang, Liaoning, China
Sao Paulo, , Brazil
Porto, , Portugal
Baton Rouge, Louisiana, United States
Meldola, Emilia Romagna, Italy
Joinville, Santa Catarina, Brazil
Jaú, São Paulo, Brazil
Barnet, , United Kingdom
Chivilcoy, Buenos Aires, Argentina
Kashiwa, Chiba, Japan
Tokyo, , Japan
Kitakyushu Shi, Fukuoka, Japan
Sapporo, Hokkaido, Japan
Chiba, , Japan
Fukuoka, , Japan
Hiroshima, , Japan
Kumamoto, , Japan
Tokyo, , Japan
Rome, Roma, Italy
Nagasaki, , Japan
Salvador, Bahia, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Rio De Janeiro, , Brazil
Sao Paulo, , Brazil
Shiwa Gun Yahaba Cho, Iwate, Japan
Kamakura, Kanagawa, Japan
Iruma, Saitama, Japan
Koshigaya, Saitama, Japan
Nagaizumi Cho,Sunto Gun, Shizuoka, Japan
Itabashiku, Tokyo, Japan
Fukuoka, , Japan
Seoul, , Korea, Republic Of
Sint Niklaas, Oost Vlaanderen, Belgium
Kansas City, Kansas, United States
Galway, Connaught, Ireland
Dublin, , Ireland
Marietta, Georgia, United States
Rochester, New York, United States
Spokane, Washington, United States
Buenos Aires, , Argentina
Vienna, Wien, Austria
Krems An Der Donau, , Austria
Leoben, , Austria
St. Pölten, , Austria
Wien, , Austria
Sint Niklaas, Oost Vlaanderen, Belgium
Antwerpen, , Belgium
Genk, , Belgium
Sao Paulo, , Brazil
Beijing City, Beijing, China
Beijing, Beijing, China
Beijing, Beijing, China
Chongqing, Chongqing, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Guangzhou, Guangdong, China
Zhengzhou, Henan, China
Wuhan, Hubei, China
Changsha, Hunan, China
Changsha, Hunan, China
Wuxi, Jiangsu, China
Xi'an, Shaanxi, China
Xi'an, Shaanxi, China
Qingdao, Shandong, China
Shanghai, Shanghai, China
Taiyuan, Shanxi, China
Tianjin, Tianjin, China
Hangzhou, Zhejiang, China
Ningbo, Zhejiang, China
Wenzhou, Zhejiang, China
Taiyuan, , China
Brno, Brno Město, Czechia
Ostrava, Ostrava Město, Czechia
Praha, , Czechia
Helsinki, , Finland
Marburg, Hessen, Germany
Bonn, Nordrhein Westfalen, Germany
Kiel, Schleswig Holstein, Germany
Hamburg, , Germany
Tuebingen, , Germany
Athens, Attikí, Greece
Athens, Attikí, Greece
Thessaloniki, Thessaloníki, Greece
Galway, Connaught, Ireland
Cork, , Ireland
Dublin, , Ireland
Kfar Saba, Hamerkaz, Israel
Ramat Gan, Hamerkaz, Israel
Haifa, Hatsafon, Israel
Tel Aviv, Tall Abīb, Israel
Jerusalem, Yerushalayim, Israel
Peatch Tikva, , Israel
Busan, Busan Gwangyeoksi, Korea, Republic Of
Busan, Busan Gwangyeoksi, Korea, Republic Of
Seongnam, Gyeonggido, Korea, Republic Of
Seongnam, Gyeonggido, Korea, Republic Of
Hwasun, Jeonranamdo, Korea, Republic Of
Hwasun, Jeonranamdo, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Braga, , Portugal
Lisbon, , Portugal
Bucharest, , Romania
Cluj Napoca, , Romania
Iasi, , Romania
Palma, Illes Balears, Spain
Murcia, Murcia, Región De, Spain
Marbella, Málaga, Spain
León, , Spain
Madrid, , Spain
Airdrie, Great Britain, United Kingdom
Leicester, Leicestershire, United Kingdom
London, London, City Of, United Kingdom
Newcastle Upon Tyne, , United Kingdom
Genk, Limburg, Belgium
Antwerpen, , Belgium
Chongqing, Chongqing, China
Birtinya, Queensland, Australia
Kraków, Małopolskie, Poland
Shirley, New York, United States
Buenos Aires, , Argentina
Cambridge, England, United Kingdom
Santiago, Región Metropolitana De Santiago, Chile
Ankara, , Turkey
Cambridge, Cambridgeshire, United Kingdom
Viña Del Mar, Valparaíso, Chile
New Hyde Park, New York, United States
Santa Fe De La Vera Cruz, Santa Fe, Argentina
Cluj Napoca, , Romania
Cordoba, Córdoba, Argentina
Rosario, Santa Fe, Argentina
Buenos Aires, , Argentina
Kitakyushu Shi, Fukuoka, Japan
Nagasaki, , Japan
Słupsk, Pomorskie, Poland
Warsaw, , Poland
Ankara, , Turkey
İzmir, , Turkey
Kayseri, , Turkey
Beijing City, Beijing, China
Wollongong, New South Wales, Australia
Krems An Der Donau, , Austria
Wenzhou, Zhejiang, China
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Tauranga, Bay Of Plenty, New Zealand
Dunedin, Otago, New Zealand
Auckland, , New Zealand
Ankara, , Turkey
Sao Paulo, , Brazil
Ahmedabad, Gujarat, India
Gurugram, Haryana, India
Belagavi, Karnataka, India
Madurai, Tamil Nadu, India
Varanasi, Uttar Pradesh, India
Ludhiana, , India
Jerusalem, Yerushalayim, Israel
Itabashiku, Tokyo, Japan
Hiroshima, , Japan
León, , Spain
Cambridge, Cambridgeshire, United Kingdom
Marburg, Hessen, Germany
Puducherry, , India
Hamburg, , Germany
Santiago, Región Metropolitana De Santiago, Chile
Joinville, Santa Catarina, Brazil
Rio De Janeiro, , Brazil
Koshigaya, Saitama, Japan
Poznan, Wielkopolskie, Poland
Airdrie, Great Britain, United Kingdom
Murcia, Murcia, Región De, Spain
Montreal, Quebec, Canada
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Urumqi, Xinjiang, China
Linhai, Zhejiang, China
Iruma, Saitama, Japan
San Juan, , Puerto Rico
Baton Rouge, Louisiana, United States
Baltimore, Maryland, United States
Santiago, Región Metropolitana De Santiago, Chile
Deyang, Sichuan, China
San Diego, California, United States
Boston, Massachusetts, United States
Jackson, Mississippi, United States
Albuquerque, New Mexico, United States
Buffalo, New York, United States
Lake Success, New York, United States
Williamsville, New York, United States
Durham, North Carolina, United States
San Antonio, Texas, United States
Seattle, Washington, United States
Madison, Wisconsin, United States
Leoben, , Austria
Salvador, Bahia, Brazil
Guangzhou, Guangdong, China
Nanning, Guangxi, China
Taiyuan, , China
Tel Aviv, Tall Abīb, Israel
Peatch Tikva, , Israel
Los Alamitos, California, United States
Ridgewood, New Jersey, United States
Allentown, Pennsylvania, United States
Viña Del Mar, Valparaíso, Chile
Warsaw, Mazowieckie, Poland
Skórzewo, Wielkopolskie, Poland
Chivilcoy, Buenos Aires, Argentina
York, Pennsylvania, United States
London, London, City Of, United Kingdom
Katowice, , Poland
Prague, , Czechia
Farmington, Connecticut, United States
Detroit, Michigan, United States
Bronx, New York, United States
New Hyde Park, New York, United States
New York, New York, United States
Shirley, New York, United States
Cleveland, Ohio, United States
Mayfield Heights, Ohio, United States
Jau, São Paulo, Brazil
Shanghai, Shanghai, China
Auckland, , New Zealand
Abilene, Texas, United States
Aurora, Colorado, United States
Shreveport, Louisiana, United States
Meldola, Emilia Romagna, Italy
München, Bayern, Germany
Weiden, Bayern, Germany
Aachen, , Germany
Bamberg, , Germany
Hamburg, , Germany
Coral Springs, Florida, United States
Santiago, Región Metropolitana De Santiago, Chile
Würzburg, , Germany
Fort Myers, Florida, United States
Saint Petersburg, Florida, United States
West Palm Beach, Florida, United States
Cincinnati, Ohio, United States
Roanoke, Virginia, United States
Traunstein, Bayern, Germany
Erfurt, Thüringen, Germany
Luoyang, Henan, China
Dresden, , Germany
Norfolk, Virginia, United States
Cordoba, , Argentina
Minneapolis, Minnesota, United States
San Antonio, Texas, United States
Vancouver, Washington, United States
Pretoria, Gauteng, South Africa
Cape Town, Western Cape, South Africa
Kuilsriver, Western Cape, South Africa
Plumstead, Western Cape, South Africa
Samsun, , Turkey
Abilene, Texas, United States
Ahmedabad, Gujarat, India
Ankara, , Turkey
Abilene, Texas, United States
Liuzhou, Guangxi, China
Weiden, Bayern, Germany
Traunstein, Bayern, Germany
Dresden, , Germany
Würzburg, , Germany
Shanghai, Shanghai, China
Nîmes, , France
Centurion, Gp, South Africa
München, Bayern, Germany
Gurugram, Haryana, India
New Haven, Connecticut, United States
Hannover, Niedersachsen, Germany
Düsseldorf, Nordrhein Westfalen, Germany
Garden City, Kansas, United States
Jau, , Brazil
Thessaloniki, , Greece
Brno, , Czechia
Viedma, , Argentina
Santiago, , Chile
Santiago, , Chile
Viña Del Mar, , Chile
Lyon Cedex08, , France
Erfurt, , Germany
Kraków, , Poland
Barcelona, , Spain
Marbella, , Spain
Mumbai, Maharashtra, India
Liuzhou, Guangxi, China
München, Bayern, Germany
Kuilsriver, Western Cape, South Africa
Patients applied
Trial Officials
Bristol-Myers Squibb
Study Director
Bristol-Myers Squibb
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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