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Search / Trial NCT05521958

Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome

Launched by UNIVERSITY OF UTAH · Aug 25, 2022

Trial Information

Current as of July 01, 2025

Enrolling by invitation

Keywords

Tibial Shaft Or Tibial Plateau Fracture Acute Compartment Syndrome Without Acute Compartment Syndrome Exertional Compartment Syndrome Gene Expression Myostatin

ClinConnect Summary

Acute compartment syndrome is associated with infection, contractures, fracture non-union, and chronic pain syndromes. The most common cause of acute compartment syndrome is fracture. Individuals with compartment syndrome associated with a lower extremity fracture have demonstrated worse patient reported outcome scores compared to individuals who suffer lower extremity fractures alone.

The pathophysiology of compartment syndrome has been traditionally described as loss of tissue perfusion and subsequent cellular anoxia related to supra-physiologic pressure within a closed myofascial space....

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patient 18+ years of age. English speaking.
  • Patients with the clinical diagnosis of lower leg acute compartment syndrome secondary to tibial shaft or tibial plateau fracture.
  • Patients without clinical compartment syndrome undergoing operative intervention within 48 hours of injury for tibial shaft or tibial plateau fractures.
  • Patients with the clinical diagnosis of exertional compartment syndrome with planned surgical intervention.
  • Exclusion Criteria:
  • Non-english speaking participants

About University Of Utah

The University of Utah is a prestigious research institution known for its commitment to advancing medical knowledge and improving patient care through innovative clinical trials. With a robust infrastructure that supports a wide range of biomedical research initiatives, the university leverages its multidisciplinary expertise and state-of-the-art facilities to conduct rigorous clinical studies. By fostering collaboration among researchers, clinicians, and community partners, the University of Utah aims to translate scientific discoveries into effective therapies and interventions, ultimately enhancing health outcomes and contributing to the advancement of medical science.

Locations

Salt Lake City, Utah, United States

Patients applied

0 patients applied

Trial Officials

Justin Haller, M.D.

Principal Investigator

University of Utah Orthopaedics

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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