Reducing Blood Pressure in Mid-life Adult Binge Drinkers

Launched by THE UNIVERSITY OF TEXAS AT ARLINGTON · Aug 26, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how binge drinking affects blood pressure and blood vessel function in middle-aged adults. The study has two parts. In the first part, researchers will compare the blood pressure and nerve activity of binge drinkers to those who don’t drink alcohol or who drink moderately. In the second part, they will see how an 8-week aerobic exercise program might improve blood pressure and blood vessel function in binge drinkers.

To participate, you need to be a man or woman aged 50 to 64 years. You can be someone who doesn’t drink alcohol, drinks moderately, or binge drinks. However, you cannot have certain health issues, like diabetes or heart disease, or be a smoker. If you join, you’ll undergo tests to measure your blood pressure and how your blood vessels work, and if you're part of the second phase, you’ll participate in an exercise program. This study aims to find ways to help improve health outcomes for binge drinkers as they age.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink
• • Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).
• • Subjects who can speak and understand English.
• Exclusion Criteria:
• • a history of diabetes, cardiovascular disease, liver, or renal disease
• • current or history of smoking and illicit drug use
• • blood pressure ≥160/100 mm Hg
• • other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol\>230 mg/dl and/or LDL cholesterol\>160 mg/dl)
• • active infection (in the past 2 months)
• • a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)
• • unstable body weight (\>5% change during the past 6 months)
• • regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week)
• • current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)