Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI

Launched by MAYO CLINIC · Aug 30, 2022

Keywords

ClinConnect Summary

This clinical trial is exploring how our body’s hormones and brain regions respond to different types of food and how this affects our appetite. Researchers want to understand the differences in how we feel full or hungry when we eat tasteless calories, enjoy tasty food, or when our stomach is filled with food without calories. The goal is to learn more about how these factors work together to influence eating behavior.

To be eligible for the study, participants should be healthy individuals aged between 18 and 26 with a body mass index (BMI) between 18 and 25, and they should have maintained their weight for the three months before joining the trial. Women will be scheduled for study days during a specific part of their menstrual cycle. Participants can expect to undergo some light to moderate physical activities and will need to agree to follow the study procedures. Importantly, there are several health conditions and factors that may prevent someone from participating, such as a history of obesity, eating disorders, or certain medical conditions. If you're interested in how our bodies regulate appetite and feel you meet the criteria, this could be an exciting opportunity to contribute to important research!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • BMI 18-25 kg/m\^2.
• • Weight stable for 3 months prior to study entry.
• • For females: study days will be scheduled during the follicular phase of their menstrual cycle (i.e., the first 13 days (about 2 weeks) of the cycle).
• • Able to provide written informed consent prior to any study procedures and be willing and able to follow study procedures..
• • Ability to perform light to moderate physical activity.
• Exclusion Criteria:
• • Any contraindication for MRI scanning.
• • Any history of childhood (\> 95th percentile) or adult obesity (BMI \>30 kg/m\^2).
• • Claustrophobia.
• • High intensity training or physical activity.
• • Any contraindication for intragastric balloon insertion.
• • Any allergies to the study meals.
• • Any history of eating disorder.
• • Any substance abuse disorder (including alcohol and tobacco).
• • Any history of psychiatric disorders.
• • Any cardiovascular, endocrine, pulmonary, neurological, or gastrointestinal comorbidities.
• • Pregnancy or nursing.
• • Any history of bariatric surgery or endoscopic bariatric procedure.
• • Use of any medication or supplement that alters appetite.
• • Patient has a known history of any condition or factor judged by the investigator to prevent participation in the study or which might hinder study adherence.