Personalized Postoperative Pain Management Following Thoracic Surgery in Adults

Launched by OPALGENIX, INC · Aug 31, 2022

Keywords

ClinConnect Summary

The OpalGenix clinical trial is studying how to improve pain management for adults who have undergone major lung surgeries, such as pneumonectomy, lobectomy, or segmentectomy. These surgeries can be very painful and often lead to severe post-surgical pain, which can sometimes continue long after the operation. The goal of this study is to create personalized treatment plans that predict how much pain a patient might experience and how best to manage it, using medications like oxycodone and methadone. By comparing real patient outcomes with what is expected based on individual risk factors, the researchers hope to provide better pain relief and reduce the need for strong opioids.

To be eligible for this study, participants must be over 18 years old and classified as healthy to moderately ill by the American Society of Anesthesiologists. They should be planning to undergo one of the targeted surgeries and cannot have serious health issues, be pregnant, or be non-English speaking. The trial is not recruiting participants yet, but those who join can expect to receive personalized care to help manage their pain after surgery, potentially leading to a quicker recovery and less discomfort.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • \>18 years
• • American Society of Anesthesiologists (ASA) Physical Status 1, 2, 3
• • Undergoing thoracic surgery (TS; pneumonectomy, lobectomy and segmentectomy)
• Exclusion Criteria:
• • Children (\<18 years)
• • Pregnant women
• • American Society of Anesthesiologists (ASA) Physical Status 4 or above
• • Non-English speaking
• • Outpatient surgery
• • Concomitant additional surgical procedures
• • Significant liver and kidney dysfunction
• • Significant cardiorespiratory compromise
• • Patients with polysubstance use (e.g., cocaine, marijuana, amphetamine, etc.)