Effect of Single vs Multiple Prophylactic Antibiotic Doses on PJI Following Primary THA in Patients With OA

Launched by SOREN OVERGAARD · Sep 3, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the effect of giving either one dose or multiple doses of antibiotics to prevent infections in patients undergoing total hip replacement surgery due to osteoarthritis. The goal is to find out if a single dose of antibiotics given within 24 hours before or after surgery is just as effective as giving several doses. This research involves around 20,000 patients across various hospitals in Denmark.

To participate in this trial, you need to be an adult between the ages of 65 and 74 who is having a total hip replacement surgery for osteoarthritis. However, if your surgery is due to a fracture or a bone tumor, you won't be eligible. If you join the study, you'll be randomly assigned to receive either the single or multiple doses of antibiotics, and researchers will monitor you to see if you develop any infections after your surgery. This trial aims to improve treatment options and ensure the best outcomes for patients undergoing this type of surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. All patients receiving a primary Total Hip Arthroplasty (THA) due to primary and secondary causes of osteoarthritis
• Exclusion Criteria:
• • 1. Patients receiving a primary THA due to either acute or sequelae of proximal femoral or acetabular fractures
• • 2. Patients receiving a primary THA due to bone tumor or metastasis