Cognition and Imaging With Tigertriever

Launched by RAPID MEDICAL · Sep 4, 2022

Keywords

ClinConnect Summary

The COGNITIVE Study is designed to explore whether a device called the Tigertriever can help improve thinking and memory skills in people who have had a stroke. Specifically, the trial is focusing on patients who have a blockage in a large blood vessel in the brain and are treated with the Tigertriever as the first option. By participating, you’ll help researchers understand if successful treatment with this device not only restores blood flow but also benefits cognitive function.

To be eligible for the study, participants should be between 18 and 75 years old, have had a stroke caused by a large vessel blockage, and have had no significant disability before the stroke. People who have had certain recent medical issues or conditions, such as brain bleeding or severe depression, may not qualify. If you join the study, you will be asked to provide consent and will need to return for follow-up assessments about six months later to see how you’re doing. This research is important for finding better ways to help stroke survivors regain their cognitive abilities.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients admitted with large vessel occlusion (LVO) and treated with the Tigertriever, as indicated per the approved IFU.
• • 2. Tigertriever was used as the first line treatment in the target vessel.
• • 3. A signed informed consent.
• • 4. Age 18-75 years (inclusive).
• • 5. No known significant pre-stroke disability (pre-stroke mRS 0 or 1).
• Exclusion Criteria:
• • 1. Use of any other IA recanalization device prior to the Tigertriever in the target vessel, including aspiration catheter.
• • 2. Evidence of acute brain hemorrhage on CT and/or MRI at admission.
• • 3. Prior hemorrhage, stroke, thrombolysis, and/or endovascular therapy in the last 3 months.
• • 4. Probable cerebral amyloid angiopathy.
• • 5. Pre-stroke diagnosed dementia and/or prescribed cholinesterase inhibitors.
• • 6. Pre-stroke diagnosed and/or currently treated major depression.
• • 7. Pre-stroke learning or intellectual disability.
• • 8. Anticipated inability to obtain 6-month follow-up assessments.
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