Xylitol vs Saline Nasal Irrigations in CF-CRS

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Sep 2, 2022

Keywords

ClinConnect Summary

Cystic fibrosis (CF) is the most common genetic disorder in Belgium, affecting 1 in 2850 children. A defect in the CFTR channel results in increased viscosity of extracellular secretions and decreased mucociliary clearance in the airways. As a result of this mechanism, chronic rhinosinusitis (CRS) occurs in nearly 100% of CF patients. CRS can lead to pronounced sinonasal complaints and can have a negative impact on the quality of life of CF patients. In addition, several studies have shown that poor upper airway control has a negative impact on the lower airways. Unfortunately, treatment op...

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Eligibility criteria

• Inclusion Criteria:
• • Patients with established diagnosis of cystic fibrosis \> 18 years old
• • Routine follow-up at UZ Leuven
• • Patients with established diagnosis of chronic rhinosinusitis, with or without nasal polyps, and with a VAS-score of \>30 out of 100 for at least one individual sinonasal symptom (nasal obstruction, rhinorrhea, postnasal drip, facial pain/pressure, reduced smell)
• • Willing to participate in this study and compliant to the treatment
• Exclusion Criteria:
• • Patients \<18 years old
• • Start of CFTR gene-modulator less than 6 months prior to inclusion
• • Not willing to participate in this trial or incompliant to the trial
• • History of severe epistaxis (\<6 months), requiring intervention by an ENT specialist
• • History of hypersensitivity/allergic reaction/anaphylactic shock to one of the compounds of the sachets (NaCl, bicarbonate, mint, Xylitol)