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Search / Trial NCT05532046

A Study to Learn How Safe Study Drug BAY2413555 is, How it Affects the Body, and How it Moves Into, Through, and Out of the Body Over 4 Weeks of Use in Participants With Heart Failure and Implanted Cardiac Defibrillator or Cardiac Resynchronization Devices (ICD/CRT)

Launched by BAYER · Sep 5, 2022

Trial Information

Current as of July 22, 2025

Terminated

Keywords

ClinConnect Summary

No description provided

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Providing signed informed consent
  • Diagnosis of heart failure lasting for at least 3 months, New York Heart Association (NYHA) functional class I-III prior to Visit 1
  • Left ventricular ejection fraction (LVEF) ≤ 45% as documented by any imaging modality within the past 12 months prior to Visit 1
  • Treatment with Guideline-Directed Medical Therapy Including with mandatory betablocker treatment with either Metoprolol, Carvedilol, Bisoprolol or Nebivolol on stable, highest individually tolerated dose for at least 2 weeks prior to Visit 1
  • Implanted cardiac defibrillator (ICD) with pacemaker backup function OR cardiac resynchronization device (CRT)
  • first implantation at least 3 months prior to Visit 1
  • Exclusion Criteria:
  • Permanent atrial fibrillation or other than Sinus rhythm at Visit 1
  • History of higher degree atrioventricular (AV) block (Mobitz type II or third-degree AV block) within 4 weeks prior to Visit 1
  • * Indication for or planned procedure:
  • Planned cardiac surgery, carotid angioplasty or surgery, transcatheter aortic valve implantation (TAVI) or mitral valve clipping within 3 months starting from the Screening Visit
  • Percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) or implantation of a cardiac resynchronization therapy defibrillator device indicated at Screening or planned within 3 months starting from the Screening Visit
  • Valvular Disease Repair indicated at Screening or planned within 3 months starting from the Screening Visit.
  • * Occurrence of any of the following within 4 weeks prior to Visit 1:
  • Myocardial infarction
  • Stroke or transient ischemic attack (TIA)
  • coronary artery bypass graft (CABG)
  • percutaneous coronary intervention (PCI)
  • Carotid angioplasty
  • Ablation therapy of atrial fibrillation or other rhythm abnormalities
  • Heart rate (HR) \> 100 bpm at Screening Visit
  • Restrictive, infiltrative or hypertrophic cardiomyopathy, constrictive pericarditis, acute myocarditis within 3 months prior to Visit 1
  • Malignancy of the hematological system within 5 years prior to the Screening Visit
  • Listed for heart transplantation and/or anticipated implantation of a ventricular assist device at the Screening Visit
  • Hepatic insufficiency classified as Child-Pugh B or C at the Screening Visit
  • Estimated (according to the investigator's judgement) inability to perform exercise testing
  • Any of the following from the blood sample taken at the Screening Visit
  • Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m\^2 (calculated according to the Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] equation)
  • Hemoglobin \< 11 g/dL
  • White blood cell (WBC) \< 3000/mm\^3
  • Thrombocytes \< 100 000/mm\^3
  • Currently receiving or planned to receive dialysis or ultrafiltration
  • Chronic obstructive pulmonary disease (COPD) Stage 3 or 4 (GOLD criteria), requiring treatment, or symptomatic asthma requiring current treatment
  • Prior or concomitant therapy with cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors or inducers.
  • Relevant substances need to be discontinued
  • at least 2 weeks before randomization for CYP3A4 inducers
  • at least 5 half-lives before randomization for CYP3A4 inhibitors Restarting of these therapies is possible 28 days after last intake of study intervention. This criterion also applies to other inhibitors of CYP3A4, e.g., grapefruit.
  • Prior and concomitant therapy with amiodarone is allowed.
  • Concomitant treatment with acetylcholine esterase inhibitors within 4 weeks prior to Visit 1
  • Use of other investigational drugs. Previous (within 4 weeks, or 5 half-lives of the investigational drug, whichever is longer, prior to Visit 1) or concomitant participation in another clinical study with investigational medicinal product(s) or device(s)
  • Life expectancy \< 6 months at the Screening Visit

About Bayer

Bayer is a global healthcare and life sciences company dedicated to advancing health and well-being through innovative research and development. With a strong commitment to improving patient outcomes, Bayer conducts clinical trials across various therapeutic areas, including oncology, cardiology, and women's health. The company leverages cutting-edge science and technology to develop breakthrough therapies, while adhering to the highest standards of ethical practices and regulatory compliance. Through collaboration with healthcare professionals and research institutions, Bayer aims to bring transformative solutions to the market, ultimately enhancing the quality of life for patients worldwide.

Locations

Durham, North Carolina, United States

Omaha, Nebraska, United States

Blackpool, Lancashire, United Kingdom

Valencia, , Spain

Córdoba, , Spain

London, , United Kingdom

Cardiff, , United Kingdom

Hellerup, , Denmark

Omaha, Nebraska, United States

København ø, , Denmark

Graz, Steiermark, Austria

Coventry, , United Kingdom

Jerusalem, , Israel

Brno, , Czechia

Málaga, , Spain

Valencia, , Spain

Aarhus N, , Denmark

Camp Hill, Pennsylvania, United States

Debrecen, , Hungary

Clydebank, West Dunbartonshire, United Kingdom

Oklahoma City, Oklahoma, United States

Schwerin, Mecklenburg Vorpommern, Germany

Praha 4, , Czechia

Innsbruck, Tirol, Austria

Praha 2, , Czechia

Multiple Locations, , Germany

Brescia, Lombardia, Italy

Milano, Lombardia, Italy

Haifa, , Israel

Sofia, , Bulgaria

Bergamo, Lombardia, Italy

St. Pölten, Niederösterreich, Austria

Dresden, Sachsen, Germany

Multiple Locations, , United Kingdom

Multiple Locations, , Italy

Multiple Locations, , Spain

Wien, , Austria

L'hospitalet De Llobregat, Barcelona, Spain

Sofia, , Bulgaria

Multiple Locations, , Denmark

Zefat, , Israel

Zrifin, , Israel

Roskilde, , Denmark

Budapest, , Hungary

Nahariya, , Israel

Pisa, Toscana, Italy

Multiple Locations, , Czechia

Multiple Locations, , Israel

Silver Spring, Maryland, United States

Ceske Budejovice, , Czechia

Praha 6, , Czechia

Wien, , Austria

Ashkelon, , Israel

Valencia, , Spain

Atlanta, Georgia, United States

Odense C, , Denmark

Singen, Baden Württemberg, Germany

Greifswald, Mecklenburg Vorpommern, Germany

Göttingen, Niedersachsen, Germany

Hagen, Nordrhein Westfalen, Germany

Babio Beade, Pontevedra, Spain

Barcelona, , Spain

Dundee, Dundee City, United Kingdom

Massa Carrara, Toscana, Italy

Córdoba, , Spain

Sofia, , Bulgaria

Pecs, , Hungary

Hellerup, , Denmark

Rennes, , France

Ceske Budejovice, , Czechia

Bron Cedex, , France

La Tronche, , France

Paris, , France

L'hospitalet De Llobregat, Barcelona, Spain

Plovdiv, , Bulgaria

Barcelona, , Spain

Málaga, , Spain

Ashkelon, , Israel

Dresden, Sachsen, Germany

Roskilde, , Denmark

Haifa, , Israel

Zefat, , Israel

Milano, Lombardia, Italy

Pisa, Toscana, Italy

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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