A Study to Learn How Safe Study Drug BAY2413555 is, How it Affects the Body, and How it Moves Into, Through, and Out of the Body Over 4 Weeks of Use in Participants With Heart Failure and Implanted Cardiac Defibrillator or Cardiac Resynchronization Devices (ICD/CRT)
Launched by BAYER · Sep 5, 2022
Trial Information
Current as of July 22, 2025
Terminated
Keywords
ClinConnect Summary
No description provided
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Providing signed informed consent
- • Diagnosis of heart failure lasting for at least 3 months, New York Heart Association (NYHA) functional class I-III prior to Visit 1
- • Left ventricular ejection fraction (LVEF) ≤ 45% as documented by any imaging modality within the past 12 months prior to Visit 1
- • Treatment with Guideline-Directed Medical Therapy Including with mandatory betablocker treatment with either Metoprolol, Carvedilol, Bisoprolol or Nebivolol on stable, highest individually tolerated dose for at least 2 weeks prior to Visit 1
- • Implanted cardiac defibrillator (ICD) with pacemaker backup function OR cardiac resynchronization device (CRT)
- • first implantation at least 3 months prior to Visit 1
- Exclusion Criteria:
- • Permanent atrial fibrillation or other than Sinus rhythm at Visit 1
- • History of higher degree atrioventricular (AV) block (Mobitz type II or third-degree AV block) within 4 weeks prior to Visit 1
- * Indication for or planned procedure:
- • Planned cardiac surgery, carotid angioplasty or surgery, transcatheter aortic valve implantation (TAVI) or mitral valve clipping within 3 months starting from the Screening Visit
- • Percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) or implantation of a cardiac resynchronization therapy defibrillator device indicated at Screening or planned within 3 months starting from the Screening Visit
- • Valvular Disease Repair indicated at Screening or planned within 3 months starting from the Screening Visit.
- * Occurrence of any of the following within 4 weeks prior to Visit 1:
- • Myocardial infarction
- • Stroke or transient ischemic attack (TIA)
- • coronary artery bypass graft (CABG)
- • percutaneous coronary intervention (PCI)
- • Carotid angioplasty
- • Ablation therapy of atrial fibrillation or other rhythm abnormalities
- • Heart rate (HR) \> 100 bpm at Screening Visit
- • Restrictive, infiltrative or hypertrophic cardiomyopathy, constrictive pericarditis, acute myocarditis within 3 months prior to Visit 1
- • Malignancy of the hematological system within 5 years prior to the Screening Visit
- • Listed for heart transplantation and/or anticipated implantation of a ventricular assist device at the Screening Visit
- • Hepatic insufficiency classified as Child-Pugh B or C at the Screening Visit
- • Estimated (according to the investigator's judgement) inability to perform exercise testing
- • Any of the following from the blood sample taken at the Screening Visit
- • Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73 m\^2 (calculated according to the Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] equation)
- • Hemoglobin \< 11 g/dL
- • White blood cell (WBC) \< 3000/mm\^3
- • Thrombocytes \< 100 000/mm\^3
- • Currently receiving or planned to receive dialysis or ultrafiltration
- • Chronic obstructive pulmonary disease (COPD) Stage 3 or 4 (GOLD criteria), requiring treatment, or symptomatic asthma requiring current treatment
- • Prior or concomitant therapy with cytochrome P450 isoenzyme 3A4 (CYP3A4) inhibitors or inducers.
- • Relevant substances need to be discontinued
- • at least 2 weeks before randomization for CYP3A4 inducers
- • at least 5 half-lives before randomization for CYP3A4 inhibitors Restarting of these therapies is possible 28 days after last intake of study intervention. This criterion also applies to other inhibitors of CYP3A4, e.g., grapefruit.
- • Prior and concomitant therapy with amiodarone is allowed.
- • Concomitant treatment with acetylcholine esterase inhibitors within 4 weeks prior to Visit 1
- • Use of other investigational drugs. Previous (within 4 weeks, or 5 half-lives of the investigational drug, whichever is longer, prior to Visit 1) or concomitant participation in another clinical study with investigational medicinal product(s) or device(s)
- • Life expectancy \< 6 months at the Screening Visit
About Bayer
Bayer is a global healthcare and life sciences company dedicated to advancing health and well-being through innovative research and development. With a strong commitment to improving patient outcomes, Bayer conducts clinical trials across various therapeutic areas, including oncology, cardiology, and women's health. The company leverages cutting-edge science and technology to develop breakthrough therapies, while adhering to the highest standards of ethical practices and regulatory compliance. Through collaboration with healthcare professionals and research institutions, Bayer aims to bring transformative solutions to the market, ultimately enhancing the quality of life for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Durham, North Carolina, United States
Omaha, Nebraska, United States
Blackpool, Lancashire, United Kingdom
Valencia, , Spain
Córdoba, , Spain
London, , United Kingdom
Cardiff, , United Kingdom
Hellerup, , Denmark
Omaha, Nebraska, United States
København ø, , Denmark
Graz, Steiermark, Austria
Coventry, , United Kingdom
Jerusalem, , Israel
Brno, , Czechia
Málaga, , Spain
Valencia, , Spain
Aarhus N, , Denmark
Camp Hill, Pennsylvania, United States
Debrecen, , Hungary
Clydebank, West Dunbartonshire, United Kingdom
Oklahoma City, Oklahoma, United States
Schwerin, Mecklenburg Vorpommern, Germany
Praha 4, , Czechia
Innsbruck, Tirol, Austria
Praha 2, , Czechia
Multiple Locations, , Germany
Brescia, Lombardia, Italy
Milano, Lombardia, Italy
Haifa, , Israel
Sofia, , Bulgaria
Bergamo, Lombardia, Italy
St. Pölten, Niederösterreich, Austria
Dresden, Sachsen, Germany
Multiple Locations, , United Kingdom
Multiple Locations, , Italy
Multiple Locations, , Spain
Wien, , Austria
L'hospitalet De Llobregat, Barcelona, Spain
Sofia, , Bulgaria
Multiple Locations, , Denmark
Zefat, , Israel
Zrifin, , Israel
Roskilde, , Denmark
Budapest, , Hungary
Nahariya, , Israel
Pisa, Toscana, Italy
Multiple Locations, , Czechia
Multiple Locations, , Israel
Silver Spring, Maryland, United States
Ceske Budejovice, , Czechia
Praha 6, , Czechia
Wien, , Austria
Ashkelon, , Israel
Valencia, , Spain
Atlanta, Georgia, United States
Odense C, , Denmark
Singen, Baden Württemberg, Germany
Greifswald, Mecklenburg Vorpommern, Germany
Göttingen, Niedersachsen, Germany
Hagen, Nordrhein Westfalen, Germany
Babio Beade, Pontevedra, Spain
Barcelona, , Spain
Dundee, Dundee City, United Kingdom
Massa Carrara, Toscana, Italy
Córdoba, , Spain
Sofia, , Bulgaria
Pecs, , Hungary
Hellerup, , Denmark
Rennes, , France
Ceske Budejovice, , Czechia
Bron Cedex, , France
La Tronche, , France
Paris, , France
L'hospitalet De Llobregat, Barcelona, Spain
Plovdiv, , Bulgaria
Barcelona, , Spain
Málaga, , Spain
Ashkelon, , Israel
Dresden, Sachsen, Germany
Roskilde, , Denmark
Haifa, , Israel
Zefat, , Israel
Milano, Lombardia, Italy
Pisa, Toscana, Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials