Biomarkers Predicting Acute Myocardial Infraction in Patients Without Standard Modifiable Risk Factors

Launched by ARISTOTLE UNIVERSITY OF THESSALONIKI · Sep 6, 2022

Keywords

ClinConnect Summary

This clinical trial is studying the risk factors that can lead to a heart attack (known as an acute myocardial infarction or AMI) in patients who do not have the usual risk factors, such as high blood pressure, high cholesterol, diabetes, or smoking. Surprisingly, research shows that a significant number of people who experience heart attacks do not have these standard risk factors, and this number appears to be increasing. The goal of this study is to compare two groups of heart attack patients—those with standard risk factors and those without—to identify other possible indicators, called biomarkers, that could predict the risk of a heart attack in patients who seem healthy.

To be eligible for this trial, participants must be over 25 years old and have been hospitalized for a heart attack, confirmed by specific tests. They also need to have undergone a procedure called coronary angiography, which looks for blockages in the heart's arteries. If someone has had a heart attack before, or has certain known health conditions like high blood pressure or diabetes, they would not qualify for the study. Participants in this trial can expect to undergo various tests, including blood tests and imaging of the heart, to help researchers better understand the links between different health profiles and heart attacks without standard risk factors. This information could eventually lead to new ways to identify patients at risk for heart problems, even if they don't have the usual warning signs.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age \>25 years
• • Hospitalization for acute myocardial infarction (AMI) with or without ST elevation (based on Fourth Universal Definition of Myocardial Infarction)
• • Coronary angiography before or after hospitalization for AMI, in which at least one stenosis \>50% in a major epicardial coronary artery (left anterior descending artery, left circumflex artery, right coronary artery) or a branch thereof with a diameter of at least 2 mm was observed.
• Exclusion Criteria:
• • Inability or refusal to provide informed consent
• • Age \>90 years
• • History of hospitalization due to AMI prior to the present AMI
• • History of coronary revascularization prior to the present AMI AMI
• Exclusion Criteria for SMuRF-less patients group only:
• • Known history of hypertension and/or antihypertensive treatment prior to AMI
• • Use of tobacco products on a systematic basis for up to \<60 months (5 years) before AMI
• • History of diabetes mellitus type 1 or 2 and/or treatment with antidiabetic tablets or insulin before AMI or diagnosis of diabetes mellitus based on HbA1c during AMI hospitalization
• • Known hypercholesterolemia (total chol \>200 mg/dl / LDLc \>150 mg/dl) or treatment with statins or PCSK9is, before AMI