Role of Gut Microbiota in the Pathophysiology of Aseptic Abscesses

Launched by UNIVERSITY HOSPITAL, CLERMONT-FERRAND · Sep 8, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a rare condition called aseptic abscess syndrome (AA), where patients develop deep abscesses—painful lumps filled with pus—without any bacteria found in their bodies. Since antibiotics don’t work for this condition, doctors often use anti-inflammatory medications like corticosteroids to help patients feel better. The researchers want to learn more about the role of gut bacteria in this syndrome, especially since gut health is important for our immune system. They will collect samples from patients and healthy individuals to see if there are differences in gut bacteria and other biological markers related to AA.

To participate in this trial, adults aged 65 to 74 who have been diagnosed with aseptic abscess syndrome may be eligible if they have certain signs of the condition, such as deep abscesses that have been examined through imaging and lab tests showing no infection. Participants will need to be able to give consent and be part of the Social Security system. Those living with the patient, such as family members or close contacts, may also participate as healthy controls. Throughout the study, participants can expect to provide stool, blood, saliva, and urine samples, which will help researchers understand the link between gut bacteria and this syndrome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * For cases: adult patients meeting the diagnostic criteria for aseptic abscess syndrome described by André et al:
• • Deep abscesses on radiological examination with neutrophilic features proven by pathological analysis of a surgical specimen or biopsy when performed
• • Negative blood cultures, negative serological tests for bacteria, including always Yersinia enterocolitica, and, during surgery or aspiration, sterile pus (with standard cultures, BAAR and fungal tests) Failure of antibiotic therapy, when prescribed, after at least 2 weeks for conventional antibiotic therapy and at least 3 months for anti-tuberculosis treatment
• • Rapid clinical improvement the day after the prescription of corticosteroids (at least 1/2 mg/kg prednisone or equivalent) followed by radiological improvement after 1 month of corticosteroids, sometimes in association with immunosuppressive treatments.
• • For controls: adult person living in the same environment as the case to which it is matched. Adult person living in the same household or near the patient.
• For cases and controls:
• • Ability to provide informed consent.
• • Membership in the Social Security system.
• Exclusion Criteria:
• • Pregnant women. Incapable patients Patients deprived of liberty Antibiotic therapy administered within 6 weeks prior to inclusion.