A Prospective Observation Registry Study on the Alimentary Reconstruction After Radical Proximal Gastrectomy

Launched by SHANGHAI ZHONGSHAN HOSPITAL · Sep 13, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at different methods of reconstructing the digestive system after surgery to remove cancer from the upper stomach, specifically for patients with a type of stomach cancer called proximal gastric adenocarcinoma. The goal is to see which reconstruction technique is the safest and most effective for patients after this surgery. The study is currently recruiting participants aged 18 to 80 who have a specific type of stomach cancer and are expected to have a successful surgery.

If you or a loved one are considering joining this trial, you will go through a thorough screening process to ensure eligibility, which includes having the cancer located in the upper stomach and meeting certain health criteria. Participants will receive close monitoring throughout the study to assess their recovery and the effectiveness of the reconstruction methods used. It's important to note that everyone involved will need to provide their written consent to participate. This trial aims to improve outcomes for future patients facing similar surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Aged 18-80 years
• • Tumor located in the upper or esophagogastric junction (EGJ), and curative resection with more than 1/2 remant is expected to be achievable by proximal gastrectomy with D2 lymphadenectomy (also apply to multiple primary cancers);
• • Clinical stage T1NxM0 (According to AJCC-8th TNM staging system) of the upper stomach or diameter of EGJ cancer less than 4cm with invading esophgus no more than 2cm without any distant metastasis;
• • Primary lesion is pathologically diagnosed as gastric adenocarcinoma, such as papillary adenocarcinoma, tubular adenocarcinoma, mucinous adenocarcinoma, poorly cohesive carcinoma (including signet ring cell carcinoma and other variants), and mixed adenocarcinoma;
• • Preoperative performance status (ECOG，Eastern Cooperative Oncology Group) of 0 or 1
• • Preoperative ASA (American Society of Anesthesiologists) scoring: I-III
• • Sufficient organ functions
• • Written informed consent
• Exclusion Criteria:
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