Ketone Ester and Acute Salt (KEAS) in Young Adults

Launched by AUBURN UNIVERSITY · Sep 15, 2022

Keywords

ClinConnect Summary

This clinical trial, called the Ketone Ester and Acute Salt (KEAS) study, is looking at whether taking a ketone supplement can help protect young adults from the negative effects of eating too much salt. Many Americans consume more salt than recommended, which can lead to high blood pressure and increase the risk of heart and kidney problems. The researchers want to find out if ketone supplements can prevent these issues caused by high salt intake, which has shown promise in animal studies.

To participate in this study, you need to be between 18 and 39 years old, have a resting blood pressure lower than 150/90, and a body mass index (BMI) under 35. You should also be generally healthy, without any major diseases like diabetes or heart issues. If you join, you’ll be asked to consume a high-salt diet and take a ketone supplement while the researchers monitor your blood pressure, blood vessel function, and kidney health. This study aims to understand how ketones might help and could lead to new ways to manage the effects of high salt consumption.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between the ages of 18-39
• • Resting blood pressure no higher than 150/90
• • BMI below 35 kg/m2 (or otherwise healthy)
• • Free of any metabolic disease (diabetes or renal), pulmonary disorders (COPD or cystic fibrosis), cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular), no autoimmune diseases, and no history of cancer
• • Do not have any precluding medical conditions (i.e. hemophilia) or medication (Pradaxa, Eliquis, etc.) that prevent participants from giving blood
• • Participants must be able to cycle on an exercise bike for up to one hour at a time.
• Exclusion Criteria:
• • High blood pressure - greater the 150/90 mmHg
• • Low blood pressure - less than 90/50 mmHg
• • History of cardiovascular disease
• • History of cancer
• • History of diabetes
• • History of kidney disease
• • Obesity (BMI \> 30 kg/m2)
• • Smoking or tobacco use
• • Current pregnancy
• • Nursing mothers
• • Communication barriers