Detection and Management of Sinusitis in a Single-center Prospective Cohort of Patients with Exudative AMD (SINE)

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · Sep 19, 2022

Keywords

ClinConnect Summary

The SINE clinical trial is investigating the connection between sinusitis, an infection of the sinuses, and age-related macular degeneration (AMD), a condition that affects vision. Researchers at the Fondation Adolphe de Rothschild Hospital have noticed that some patients with wet AMD experienced improvements in their eye condition after treating their sinusitis. The goal of this study is to see if treating sinusitis can help reduce the need for eye injections in patients with AMD.

To participate in the trial, you must be at least 18 years old and have been receiving treatment for bilateral wet AMD for at least two years, with a history of needing a certain number of eye injections in the past year. If you meet these criteria and are willing to consent to the study, you may be eligible to join. Participants will receive evaluations related to their sinusitis and AMD, and the findings could help improve treatment options for others facing similar conditions. It's important to note that individuals with certain medical conditions or treatments, like severe myopia or current sinusitis treatment, will not be eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Patient followed and treated for at least 2 years for bilateral neovascular form of age-related macular degeneration (AMD)
• • At least one eye treated with ≥ 6 intravitreal injections during the year preceding preinclusion
• • Express consent to participate in the study
• • Affiliated with or beneficiary of a social security plan
• Exclusion Criteria:
• • Persons referred to in articles L1121-5 to L1121-8 of the CSP (corresponding to all protected persons: pregnant women, parturients, nursing mothers, persons deprived of liberty by judicial or administrative decision, minors, and persons under legal protection: guardianship or curatorship).
• • Severe myopia (\> 6 diopters)
• • Patient already being treated for acute or chronic sinusitis
• • History of central serous chorioretinopathy or diffuse retinal epitheliopathy