Linezolid for Syphilis Pilot Study

Launched by UNIVERSITY OF SOUTHERN CALIFORNIA · Sep 16, 2022

Keywords

ClinConnect Summary

The Linezolid for Syphilis Pilot Study is a research trial aimed at exploring whether the antibiotic linezolid can effectively treat syphilis, a sexually transmitted infection. The study is currently recruiting participants who are 16 years of age or older and have been diagnosed with primary, secondary, or early latent syphilis. To be eligible, participants must also have a specific blood test result indicating the presence of the infection and, if they are living with HIV, must be on treatment with a controlled viral load.

Participants in this trial can expect to receive linezolid as part of their treatment. They will be closely monitored throughout the study, and their health will be evaluated to determine how well the medication works against syphilis. However, certain individuals cannot participate, including those who are pregnant, have specific mental health medication prescriptions, or have recent treatment with certain antibiotics. This study is an important step in finding new treatment options for syphilis and could contribute to better care for those affected by this infection.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 16 years of age or older
• • Diagnosed cases of primary, secondary, or early latent syphilis with RPR titer ≥1:8 within 3 weeks prior to enrollment
• • Able to provide informed consent
• • For PLHIV: on treatment for HIV-infection and most recent viral load \<200 copies/mL or most recent CD4 T-cell count \>350 cells/mL
• Exclusion Criteria:
• • Pregnancy or a positive pregnancy test on the day of enrollment
• • Participants who receive certain psychotropic medications, e.g., MAO inhibitors, SNRIs, SSRIs
• • Patients showing signs and symptoms of neurosyphilis
• • Serofast RPR titer
• • Recent (\<7 days) or concomitant antimicrobial therapy with azithromycin, doxycycline, ceftriaxone, cefixime, or other beta lactam antibiotics (e.g. amoxicillin)
• • Linezolid or penicillin allergy