Intraoperative Hypocapnia in PROVHILO and PROBESE
Launched by NMC SPECIALTY HOSPITAL · Sep 21, 2022
Trial Information
Current as of May 12, 2025
Completed
Keywords
ClinConnect Summary
Lung-protective intraoperative ventilation (LPV) has the potential to improve the outcome of surgery patients through a reduction in postoperative pulmonary complications. Use of intraoperative ventilation strategies that use a low tidal volume could result in intraoperative hypercapnia. However, hypocapnia remains surprisingly common during intraoperative ventilation, possibly meaning that anesthesiologists continue to use high, if not too high respiratory rates or tidal volumes.
Previous studies suggested associations between intraoperative derangement of end-tidal carbon dioxide (etCO2)...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Planned for major (abdominal) surgery.
- • At risk for postoperative pulmonary complications.
- Exclusion Criteria:
- • Planned thoracic surgery or neurosurgery.
- • Unscheduled surgery (i.e., urgent, or emergent surgeries) were excluded because these patients may have had metabolic abnormalities at the moment of surgery, i.e., metabolic acidosis, for which the anesthesiologist may have adjusted the intraoperative ventilator settings. This may have led to a 'compensatory' low etCO2.
- • Patients with etCO2 recordings are missing from the study databases.
About Nmc Specialty Hospital
NMC Specialty Hospital is a leading healthcare institution committed to advancing medical research and patient care through innovative clinical trials. With a focus on providing high-quality, evidence-based treatments, NMC Specialty Hospital collaborates with healthcare professionals and researchers to explore new therapies and improve patient outcomes. The hospital is dedicated to maintaining the highest ethical standards and regulatory compliance, ensuring patient safety and well-being throughout the research process. By leveraging state-of-the-art facilities and a multidisciplinary approach, NMC Specialty Hospital aims to contribute significantly to the advancement of medical science and the development of effective healthcare solutions.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Barcelona, , Spain
São Paulo, , Brazil
Dresden, , Germany
Genoa, , Italy
Patients applied
Trial Officials
Sabrine NT Hemmes, PhD
Study Chair
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
David MP van Meenen, PhD
Principal Investigator
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Frederique Paulus, PhD
Study Chair
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Marcus J Schultz, PhD
Study Director
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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