Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients

Launched by ARKANSAS CHILDREN'S HOSPITAL RESEARCH INSTITUTE · Sep 19, 2022

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how certain viruses affect children who have had or are about to have a transplant, which can be a serious medical procedure. The study aims to find out if testing for respiratory viruses before the transplant can help predict if a child will develop a respiratory viral infection in the year following the transplant. Researchers will also look at the immune system's response both before and after the transplant to see if it can help predict these infections.

To participate in this study, children must be under 18 years old and scheduled to receive a hematopoietic cell transplant (a type of stem cell transplant) or a solid organ transplant. Parents or guardians will need to give permission for their child to take part. If enrolled, families can expect to provide some blood samples for testing and to be monitored for any respiratory infections during the year after the transplant. This research could help improve care for pediatric transplant patients by identifying those at higher risk for infections and potentially leading to better treatment options.

Gender

ALL

Eligibility criteria

• • Recipient Inclusion Criteria
• • Less than 18 years at the time of anticipated transplant
• * Participant meets one of the following criteria:
• • 1. scheduled to receive allogeneic hematopoietic cell transplant within 14 days of enrollment or
• • 2. Scheduled to or received solid organ transplant within 7 days before or after enrollment
• • Participant is receiving care at the time of enrollment at one of the study participating institutions.
• • Parent/guardian willing and able to provide informed consent, and if appropriate, child willing and able to provide informed assent.
• • Donor Inclusion Criteria
• • Donor for HCT recipient enrolled on the VIPER study.
• • Willing and able to provide informed consent.
• Exclusion Criteria:
• • Recipient Exclusion Criteria
• • None
• • Donor Exclusion Criteria
• • Is not an HCT donor for a participant enrolled on the VIPER study.
• • Not available to provide pre-transplant research blood sample.