HP 129Xe MRI for Evaluation of CLAD in Lung Transplant Recipients

Launched by THE HOSPITAL FOR SICK CHILDREN · Sep 21, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a special type of MRI called hyperpolarized 129Xe MRI to see how it can help evaluate lung transplant recipients who may be experiencing a condition known as Chronic Lung Allograft Dysfunction (CLAD). The goal is to determine if this imaging technique can effectively show changes in lung structure and function in these patients.

To be eligible for this trial, participants must be at least 18 years old and have received a double lung transplant. They should be clinically stable, meaning their health is considered steady by the lung transplant team. Some participants will have CLAD, while others will not, but all must have had their lung function measured within the last month. During the study, participants can expect to undergo an MRI scan, which is a painless procedure that uses magnets to create images of the lungs. It’s important to note that certain individuals, such as those who are pregnant, have specific mental health conditions, or cannot travel for the scan, may not be able to participate. This trial is currently recruiting participants, and it provides a chance to contribute to research that could improve care for lung transplant recipients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients, deemed clinically stable by the lung transplant team at UHN Toronto Lung Transplant Program (TLTP), 18 years of age or older
• • Double lung transplant recipient
• • For the 5 CLAD-free participants - at least 1 year of follow-up post-LTx and no substantial and persistent FEV1 decline (as per the ISHLT CLAD definition).
• • For the 10 participants with CLAD - prior diagnosis of CLAD made by the clinical team (member of the TLTP).
• • PFT measurements within 1 month of scan visit.
• • FEV1 \> 1.0 L
• Exclusion Criteria:
• • Currently pregnant or lactating
• • Psychiatric or addictive disorders that would preclude obtaining informed consent or adherence to protocol
• • Inability to travel to obtain MRI scan
• • Any contraindications to MRI including but not limited to severe claustrophobia, implanted devices, aneurysm clips, neurostimulators (patients will be prescreened prior to registration).
• • Baseline oxygen saturation of less than 88%.
• • Requiring supplemental oxygen at baseline