Safest Choice of Antihypertensive Regimen for Postpartum Hypertension

Launched by LOMA LINDA UNIVERSITY · Sep 19, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at the best way to manage high blood pressure that some women experience after giving birth, known as postpartum hypertension. Researchers want to compare two medications: Nifedipine and Labetalol, to see which one works better at controlling blood pressure in new mothers. If you are a woman aged 18 or older who has developed high blood pressure after delivery or has a history of high blood pressure that needs treatment, you may be eligible to participate in this study.

If you join the trial, you will be randomly assigned to receive either Nifedipine or Labetalol. The goal is to find out which medication helps you keep your blood pressure in a safe range. Participants will be monitored closely, and the study will provide more information about managing postpartum hypertension. It's important to note that women with certain health conditions or those who speak languages other than English or Spanish may not be able to participate.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female
• • Women who develop postpartum hypertension\* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.
• • Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.
• Exclusion Criteria:
• • History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
• • Contraindication to either Nifedipine or Labetalol
• • HR \<60 or \>110
• • Native language other than English or Spanish